11-Ketotestosterone: Difference between revisions

Latest revision as of 06:08, 16 February 2025

11-Ketotestosterone[edit]

Chemical structure of 11-Ketotestosterone

11-Ketotestosterone is an androgenic steroid hormone that plays a significant role in the endocrine system of certain vertebrates. It is particularly important in the regulation of reproductive physiology and secondary sexual characteristics in fish and other non-mammalian species.

Chemical Structure[edit]

11-Ketotestosterone is a derivative of testosterone, characterized by the presence of a ketone group at the 11th carbon position. This modification distinguishes it from other androgens and influences its biological activity.

Biological Role[edit]

In many teleost fish, 11-ketotestosterone is the primary androgen responsible for the development and maintenance of male characteristics. It is involved in the regulation of spermatogenesis, the process by which spermatozoa are produced. Additionally, it influences the development of secondary sexual characteristics such as coloration and behavior during the breeding season.

Synthesis and Metabolism[edit]

11-Ketotestosterone is synthesized from testosterone through the action of specific enzymes that convert the hydroxyl group at the 11th position to a ketone. This conversion is crucial for its activity in non-mammalian species. The hormone is metabolized in the liver and excreted in the urine.

Clinical Significance[edit]

While 11-ketotestosterone is not a major androgen in humans, its role in fish makes it a valuable marker for studying endocrine disruption in aquatic environments. It is often measured in studies assessing the impact of pollutants on fish populations.

Related Pages[edit]

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-{{short description|A potent androgenic steroid}}
+== 11-Ketotestosterone ==
-{{DISPLAYTITLE:11-Ketotestosterone}}
-'''11-Ketotestosterone''' is a potent [[androgen]]ic steroid that plays a significant role in the [[endocrine system]] of various [[vertebrates]]. It is particularly important in the regulation of [[reproductive]] and [[secondary sexual characteristics]] in [[fish]] and other non-mammalian species.
+[[File:11-Ketotestosterone.svg|thumb|right|Chemical structure of 11-Ketotestosterone]]
-==Structure and Synthesis==
+'''11-Ketotestosterone''' is an [[androgen]]ic steroid hormone that plays a significant role in the [[endocrine system]] of certain [[vertebrates]]. It is particularly important in the regulation of [[reproductive physiology]] and [[secondary sexual characteristics]] in [[fish]] and other non-mammalian species.
--Ketotestosterone is a derivative of [[testosterone]], characterized by the presence of a keto group at the 11th carbon position. This modification distinguishes it from other androgens and contributes to its unique biological activity.
-The synthesis of 11-ketotestosterone involves the conversion of [[testosterone]] through enzymatic pathways that include the action of 11_-hydroxysteroid dehydrogenase. This enzyme catalyzes the oxidation of the 11-hydroxyl group to a keto group, resulting in the formation of 11-ketotestosterone.
+== Chemical Structure ==
+-Ketotestosterone is a derivative of [[testosterone]], characterized by the presence of a ketone group at the 11th carbon position. This modification distinguishes it from other androgens and influences its biological activity.
-==Biological Role==
+== Biological Role ==
-In many [[teleost fish]], 11-ketotestosterone is the primary androgen responsible for the development and maintenance of male secondary sexual characteristics. It is involved in the regulation of [[spermatogenesis]], the process by which [[spermatozoa]] are produced.
+In many [[teleost fish]], 11-ketotestosterone is the primary androgen responsible for the development and maintenance of male characteristics. It is involved in the regulation of [[spermatogenesis]], the process by which [[spermatozoa]] are produced. Additionally, it influences the development of [[secondary sexual characteristics]] such as coloration and behavior during the [[breeding season]].
--Ketotestosterone also influences [[aggressive behavior]] and territoriality in male fish, which are critical for successful [[mating]] and reproduction. Its role in non-mammalian species highlights the diversity of androgenic regulation across different classes of vertebrates.
+== Synthesis and Metabolism ==
+-Ketotestosterone is synthesized from testosterone through the action of specific [[enzymes]] that convert the hydroxyl group at the 11th position to a ketone. This conversion is crucial for its activity in non-mammalian species. The hormone is metabolized in the liver and excreted in the urine.
-==Mechanism of Action==
+== Clinical Significance ==
-Like other androgens, 11-ketotestosterone exerts its effects by binding to the [[androgen receptor]], a type of [[nuclear receptor]] that regulates the expression of specific genes. Upon binding, the receptor-ligand complex translocates to the [[cell nucleus]], where it interacts with [[DNA]] to modulate the transcription of target genes involved in male reproductive function and secondary sexual characteristics.
+While 11-ketotestosterone is not a major androgen in humans, its role in fish makes it a valuable marker for studying [[endocrine disruption]] in aquatic environments. It is often measured in studies assessing the impact of [[pollutants]] on fish populations.
-==Clinical Significance==
+== Related Pages ==
-While 11-ketotestosterone is not a major androgen in humans, its study provides insights into the evolution of steroid hormone function and the diversity of endocrine regulation in vertebrates. Understanding its role in fish and other species can inform [[aquaculture]] practices and the management of fish populations.
-==Related Pages==
 * [[Testosterone]]
 * [[Androgen]]
 * [[Endocrine system]]
 * [[Spermatogenesis]]
+* [[Secondary sexual characteristics]]
-==Gallery==
-<gallery>
-File:11-Ketotestosterone.svg|Chemical structure of 11-Ketotestosterone
-</gallery>
 [[Category:Androgens]]
 [[Category:Steroid hormones]]
-[[Category:Endocrinology]]