Propylpyrazoletriol: Difference between revisions
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{{DISPLAYTITLE:Propylpyrazoletriol}} | |||
== | == Propylpyrazoletriol == | ||
Propylpyrazoletriol | [[File:Propylpyrazoletriol.svg|thumb|right|Chemical structure of Propylpyrazoletriol]] | ||
'''Propylpyrazoletriol''' (PPT) is a synthetic, nonsteroidal compound that acts as a selective agonist for the [[estrogen receptor]] subtype [[Estrogen receptor alpha|ER_]]. It is primarily used in scientific research to study the role of ER_ in various biological processes. | |||
== | == Chemical Properties == | ||
Propylpyrazoletriol is characterized by its pyrazole core structure, which is modified with propyl groups to enhance its selectivity and binding affinity for ER_. The chemical structure of PPT allows it to mimic the action of natural estrogens, but with a higher specificity for ER_ over other estrogen receptor subtypes such as [[Estrogen receptor beta|ER_]]. | |||
== | == Mechanism of Action == | ||
PPT binds to the ligand-binding domain of ER_, inducing a conformational change that activates the receptor. This activation leads to the transcription of estrogen-responsive genes, which are involved in a variety of physiological processes including reproductive function, bone density maintenance, and cardiovascular health. | |||
== Applications in Research == | |||
Propylpyrazoletriol is widely used in [[biomedical research]] to investigate the specific roles of ER_ in health and disease. It is particularly useful in studies aiming to differentiate the effects mediated by ER_ from those mediated by ER_. Research utilizing PPT has contributed to a better understanding of estrogen's role in [[breast cancer]], [[osteoporosis]], and [[cardiovascular disease]]. | |||
== Safety and Handling == | |||
As with many research chemicals, proper safety protocols should be followed when handling propylpyrazoletriol. It should be used in a controlled laboratory environment, with appropriate personal protective equipment such as gloves and goggles. | |||
== Related Pages == | |||
* [[Estrogen receptor]] | |||
* [[Selective estrogen receptor modulator]] | * [[Selective estrogen receptor modulator]] | ||
* [[ | * [[Breast cancer]] | ||
* [[ | * [[Osteoporosis]] | ||
[[Category:Estrogen receptor modulators]] | |||
[[Category:Research chemicals]] | |||
Latest revision as of 05:44, 16 February 2025
Propylpyrazoletriol[edit]
Propylpyrazoletriol (PPT) is a synthetic, nonsteroidal compound that acts as a selective agonist for the estrogen receptor subtype ER_. It is primarily used in scientific research to study the role of ER_ in various biological processes.
Chemical Properties[edit]
Propylpyrazoletriol is characterized by its pyrazole core structure, which is modified with propyl groups to enhance its selectivity and binding affinity for ER_. The chemical structure of PPT allows it to mimic the action of natural estrogens, but with a higher specificity for ER_ over other estrogen receptor subtypes such as ER_.
Mechanism of Action[edit]
PPT binds to the ligand-binding domain of ER_, inducing a conformational change that activates the receptor. This activation leads to the transcription of estrogen-responsive genes, which are involved in a variety of physiological processes including reproductive function, bone density maintenance, and cardiovascular health.
Applications in Research[edit]
Propylpyrazoletriol is widely used in biomedical research to investigate the specific roles of ER_ in health and disease. It is particularly useful in studies aiming to differentiate the effects mediated by ER_ from those mediated by ER_. Research utilizing PPT has contributed to a better understanding of estrogen's role in breast cancer, osteoporosis, and cardiovascular disease.
Safety and Handling[edit]
As with many research chemicals, proper safety protocols should be followed when handling propylpyrazoletriol. It should be used in a controlled laboratory environment, with appropriate personal protective equipment such as gloves and goggles.
