Testosterone stearate: Difference between revisions

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'''Testosterone stearate''' is an [[ester]] of [[testosterone]], a naturally occurring [[androgen]] hormone. It is a white, crystalline substance that is insoluble in water but soluble in organic solvents. Testosterone stearate is used in the formulation of [[pharmaceutical]] products, particularly those designed for [[hormone replacement therapy]] (HRT) and the treatment of [[hypogonadism]].
{{DISPLAYTITLE:Testosterone Stearate}}


==Chemical Structure==
== Overview ==
Testosterone stearate is formed by the esterification of the 17-beta hydroxyl group of testosterone with [[stearic acid]]. This results in a compound with the molecular formula C29H48O3. The esterification process increases the lipophilicity of the testosterone molecule, which can enhance its absorption and prolong its action in the body.
[[File:Testosterone_stearate.svg|thumb|right|Chemical structure of testosterone stearate]]
'''Testosterone stearate''' is a synthetic [[androgen]] and [[anabolic steroid]] that is a derivative of [[testosterone]]. It is an ester of testosterone, specifically the [[stearate]] ester, which is used to modify the pharmacokinetics of the parent hormone.


==Pharmacology==
== Chemical Structure ==
Testosterone stearate is a prodrug, meaning it is inactive in its administered form and must be metabolized in the body to produce its active form, testosterone. This conversion occurs primarily in the [[liver]], but also in peripheral tissues. Once converted to testosterone, it exerts its effects by binding to and activating the [[androgen receptor]], which regulates the expression of genes involved in male sexual development and function.
Testosterone stearate is characterized by the attachment of a stearate group to the 17-beta hydroxyl group of testosterone. This modification increases the lipophilicity of the molecule, allowing it to be administered in an oil-based solution for intramuscular injection.


==Clinical Use==
== Pharmacology ==
Testosterone stearate is used in the treatment of conditions associated with testosterone deficiency, such as hypogonadism and certain types of [[infertility]]. It may also be used in hormone replacement therapy for transgender men. The use of testosterone stearate and other testosterone esters is generally considered safe and effective, but it can be associated with side effects such as acne, hair loss, and increased risk of cardiovascular disease.
The esterification of testosterone with stearic acid results in a compound with a prolonged duration of action compared to unmodified testosterone. This is due to the slow release of the active hormone from the injection site into the bloodstream, where it is then hydrolyzed to free testosterone.


==See Also==
== Clinical Use ==
Testosterone stearate is used in the treatment of [[hypogonadism]] in males, where it helps to restore normal levels of testosterone. It may also be used in certain cases of delayed puberty and in hormone therapy for transgender men.
 
== Administration ==
Testosterone stearate is typically administered via intramuscular injection. The frequency of administration depends on the specific formulation and the clinical needs of the patient.
 
== Side Effects ==
As with other testosterone esters, potential side effects of testosterone stearate include [[acne]], [[gynecomastia]], [[increased red blood cell count]], and [[mood changes]]. Long-term use can lead to suppression of the hypothalamic-pituitary-gonadal axis.
 
== Related Pages ==
* [[Testosterone]]
* [[Testosterone]]
* [[Testosterone cypionate]]
* [[Androgen]]
* [[Testosterone enanthate]]
* [[Anabolic steroid]]
* [[Testosterone propionate]]
* [[Hypogonadism]]
 
* [[Hormone replacement therapy]]
==References==
<references />


[[Category:Pharmaceuticals]]
[[Category:Androgens and anabolic steroids]]
[[Category:Hormones]]
[[Category:Testosterone esters]]
[[Category:Androgens]]
[[Category:Esters]]
{{pharma-stub}}

Latest revision as of 05:32, 16 February 2025


Overview[edit]

Chemical structure of testosterone stearate

Testosterone stearate is a synthetic androgen and anabolic steroid that is a derivative of testosterone. It is an ester of testosterone, specifically the stearate ester, which is used to modify the pharmacokinetics of the parent hormone.

Chemical Structure[edit]

Testosterone stearate is characterized by the attachment of a stearate group to the 17-beta hydroxyl group of testosterone. This modification increases the lipophilicity of the molecule, allowing it to be administered in an oil-based solution for intramuscular injection.

Pharmacology[edit]

The esterification of testosterone with stearic acid results in a compound with a prolonged duration of action compared to unmodified testosterone. This is due to the slow release of the active hormone from the injection site into the bloodstream, where it is then hydrolyzed to free testosterone.

Clinical Use[edit]

Testosterone stearate is used in the treatment of hypogonadism in males, where it helps to restore normal levels of testosterone. It may also be used in certain cases of delayed puberty and in hormone therapy for transgender men.

Administration[edit]

Testosterone stearate is typically administered via intramuscular injection. The frequency of administration depends on the specific formulation and the clinical needs of the patient.

Side Effects[edit]

As with other testosterone esters, potential side effects of testosterone stearate include acne, gynecomastia, increased red blood cell count, and mood changes. Long-term use can lead to suppression of the hypothalamic-pituitary-gonadal axis.

Related Pages[edit]