CUMYL-NBMINACA: Difference between revisions

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'''CUMYL-NBMINACA''' is a [[synthetic cannabinoid]] that has been identified in illicit products. It is a potent [[agonist]] for the [[CB1 receptor]] and [[CB2 receptor]]. CUMYL-NBMINACA was first identified in Slovenia in 2017 and has since been found in a number of other countries. It is illegal in many jurisdictions, including the United States, where it is a Schedule I controlled substance.
{{DISPLAYTITLE:CUMYL-NBMINACA}}


==Chemistry==
== Overview ==
CUMYL-NBMINACA is a member of the [[indazole-3-carboxamide]] family of synthetic cannabinoids. It is structurally related to other synthetic cannabinoids such as [[5F-CUMYL-PINACA]]. The chemical formula of CUMYL-NBMINACA is C22H24N4O2.
[[File:CUMYL-NBMINACA_structure.png|thumb|right|Chemical structure of CUMYL-NBMINACA]]
'''CUMYL-NBMINACA''' is a synthetic cannabinoid that acts as a potent agonist of the [[cannabinoid receptor]]s. It is part of a class of compounds that are often used in the manufacture of [[designer drugs]]. These substances are designed to mimic the effects of [[tetrahydrocannabinol]] (THC), the active component of [[cannabis]].


==Pharmacology==
== Chemical Properties ==
CUMYL-NBMINACA is a potent agonist for the CB1 and CB2 receptors. The CB1 receptor is primarily located in the brain and is responsible for the psychoactive effects of cannabinoids. The CB2 receptor is primarily found in the immune system and is involved in immune response and inflammation.
CUMYL-NBMINACA is chemically classified as an indazole-based synthetic cannabinoid. Its full chemical name is ''N''-[[(1-(cyclohexylmethyl)-1''H''-indazole-3-carbonyl]])-''L''-valine ''methyl ester''. The compound is known for its high affinity for the [[CB1 receptor]], which is primarily responsible for the psychoactive effects associated with cannabinoids.


==Effects==
== Pharmacology ==
The effects of CUMYL-NBMINACA are similar to those of other synthetic cannabinoids and include [[euphoria]], [[relaxation]], and [[altered perception]]. However, it is significantly more potent than natural cannabinoids such as [[THC]], and this increased potency can lead to more severe adverse effects. These can include [[anxiety]], [[paranoia]], [[hallucinations]], and [[psychosis]]. In some cases, use of CUMYL-NBMINACA has been associated with serious health risks, including seizures and death.
CUMYL-NBMINACA functions as a full agonist at the [[CB1 receptor]] and [[CB2 receptor]], with a higher selectivity for the CB1 receptor. This selectivity contributes to its potent psychoactive effects. The compound's interaction with these receptors can lead to a range of effects, including [[euphoria]], [[anxiety]], and [[hallucinations]].


==Legal status==
== Usage and Effects ==
CUMYL-NBMINACA is illegal in many jurisdictions. In the United States, it is a Schedule I controlled substance, which means it is considered to have a high potential for abuse and no accepted medical use. It is also illegal in many European countries, including Slovenia, where it was first identified.
Synthetic cannabinoids like CUMYL-NBMINACA are often sprayed onto plant material and sold as "[[herbal incense]]" or "[[spice]]". Users typically smoke the treated plant material to achieve a high similar to that of cannabis. However, the effects can be unpredictable and sometimes more intense, leading to adverse reactions such as [[tachycardia]], [[hypertension]], and [[seizures]].


==See also==
== Legal Status ==
Due to its potential for abuse and lack of medical use, CUMYL-NBMINACA is classified as a controlled substance in many countries. Regulatory agencies have placed it under various schedules to restrict its distribution and use. The compound is often included in legislation targeting synthetic cannabinoids as a class.
 
== Health Risks ==
The use of CUMYL-NBMINACA has been associated with numerous health risks. Acute intoxication can result in severe [[psychosis]], [[agitation]], and [[cardiovascular complications]]. Long-term use may lead to [[addiction]] and [[withdrawal symptoms]]. The variability in potency and purity of synthetic cannabinoids further exacerbates these risks.
 
== Related Pages ==
* [[Synthetic cannabinoids]]
* [[Synthetic cannabinoids]]
* [[Indazole-3-carboxamide]]
* [[Cannabinoid receptor]]
* [[CB1 receptor]]
* [[Designer drugs]]
* [[CB2 receptor]]
* [[Tetrahydrocannabinol]]
* [[Spice (drug)]]


[[Category:Synthetic cannabinoids]]
[[Category:Synthetic cannabinoids]]
[[Category:Indazolecarboxamides]]
[[Category:Designer drugs]]
[[Category:CB1 receptor agonists]]
[[Category:CB2 receptor agonists]]
 
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Latest revision as of 05:19, 16 February 2025


Overview[edit]

Chemical structure of CUMYL-NBMINACA

CUMYL-NBMINACA is a synthetic cannabinoid that acts as a potent agonist of the cannabinoid receptors. It is part of a class of compounds that are often used in the manufacture of designer drugs. These substances are designed to mimic the effects of tetrahydrocannabinol (THC), the active component of cannabis.

Chemical Properties[edit]

CUMYL-NBMINACA is chemically classified as an indazole-based synthetic cannabinoid. Its full chemical name is N-(1-(cyclohexylmethyl)-1''H''-indazole-3-carbonyl)-L-valine methyl ester. The compound is known for its high affinity for the CB1 receptor, which is primarily responsible for the psychoactive effects associated with cannabinoids.

Pharmacology[edit]

CUMYL-NBMINACA functions as a full agonist at the CB1 receptor and CB2 receptor, with a higher selectivity for the CB1 receptor. This selectivity contributes to its potent psychoactive effects. The compound's interaction with these receptors can lead to a range of effects, including euphoria, anxiety, and hallucinations.

Usage and Effects[edit]

Synthetic cannabinoids like CUMYL-NBMINACA are often sprayed onto plant material and sold as "herbal incense" or "spice". Users typically smoke the treated plant material to achieve a high similar to that of cannabis. However, the effects can be unpredictable and sometimes more intense, leading to adverse reactions such as tachycardia, hypertension, and seizures.

Legal Status[edit]

Due to its potential for abuse and lack of medical use, CUMYL-NBMINACA is classified as a controlled substance in many countries. Regulatory agencies have placed it under various schedules to restrict its distribution and use. The compound is often included in legislation targeting synthetic cannabinoids as a class.

Health Risks[edit]

The use of CUMYL-NBMINACA has been associated with numerous health risks. Acute intoxication can result in severe psychosis, agitation, and cardiovascular complications. Long-term use may lead to addiction and withdrawal symptoms. The variability in potency and purity of synthetic cannabinoids further exacerbates these risks.

Related Pages[edit]