Dextrothyroxine: Difference between revisions
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{{DISPLAYTITLE:Dextrothyroxine}} | |||
== | == Dextrothyroxine == | ||
Dextrothyroxine was | [[File:Dextrothyroxine_skeletal.svg|thumb|right|Chemical structure of Dextrothyroxine]] | ||
'''Dextrothyroxine''' is a synthetic [[thyroid hormone]] analog that was developed for the treatment of [[hyperlipidemia]], a condition characterized by elevated levels of lipids in the blood. Unlike the naturally occurring [[thyroid hormone]] [[levothyroxine]], dextrothyroxine is the [[dextrorotatory]] isomer, meaning it rotates plane-polarized light to the right. | |||
==Mechanism of Action== | == Mechanism of Action == | ||
Dextrothyroxine functions by increasing the [[metabolic rate]] and enhancing the breakdown of [[lipids]] in the body. It acts on the [[thyroid hormone receptor]]s, although with less potency compared to [[levothyroxine]]. The primary effect of dextrothyroxine is to lower [[cholesterol]] levels, particularly [[low-density lipoprotein]] (LDL) cholesterol, which is often referred to as "bad cholesterol." | |||
== | == Clinical Use == | ||
Dextrothyroxine was initially investigated for its potential to treat [[hypercholesterolemia]] and other forms of [[dyslipidemia]]. However, its use has been limited due to concerns about [[cardiovascular]] side effects, such as [[tachycardia]] and [[arrhythmias]], which are associated with excessive thyroid hormone activity. | |||
== | == Side Effects == | ||
The side effects of dextrothyroxine are similar to those of other thyroid hormones and can include symptoms of [[hyperthyroidism]], such as increased heart rate, [[anxiety]], [[insomnia]], and [[weight loss]]. Due to these potential adverse effects, its use in clinical practice has been largely discontinued. | |||
== | == History == | ||
Dextrothyroxine was developed in the mid-20th century as researchers sought alternatives to traditional lipid-lowering therapies. Despite its initial promise, the development of more effective and safer lipid-lowering agents, such as [[statins]], has overshadowed its use. | |||
== | == Related Pages == | ||
* [[Thyroid hormone]] | * [[Thyroid hormone]] | ||
* [[Levothyroxine]] | * [[Levothyroxine]] | ||
* [[Hyperlipidemia]] | |||
* [[Cholesterol]] | |||
* [[Statins]] | |||
[[Category:Thyroid]] | [[Category:Thyroid hormones]] | ||
[[Category: | [[Category:Hypolipidemic agents]] | ||
Latest revision as of 05:17, 16 February 2025
Dextrothyroxine[edit]
Dextrothyroxine is a synthetic thyroid hormone analog that was developed for the treatment of hyperlipidemia, a condition characterized by elevated levels of lipids in the blood. Unlike the naturally occurring thyroid hormone levothyroxine, dextrothyroxine is the dextrorotatory isomer, meaning it rotates plane-polarized light to the right.
Mechanism of Action[edit]
Dextrothyroxine functions by increasing the metabolic rate and enhancing the breakdown of lipids in the body. It acts on the thyroid hormone receptors, although with less potency compared to levothyroxine. The primary effect of dextrothyroxine is to lower cholesterol levels, particularly low-density lipoprotein (LDL) cholesterol, which is often referred to as "bad cholesterol."
Clinical Use[edit]
Dextrothyroxine was initially investigated for its potential to treat hypercholesterolemia and other forms of dyslipidemia. However, its use has been limited due to concerns about cardiovascular side effects, such as tachycardia and arrhythmias, which are associated with excessive thyroid hormone activity.
Side Effects[edit]
The side effects of dextrothyroxine are similar to those of other thyroid hormones and can include symptoms of hyperthyroidism, such as increased heart rate, anxiety, insomnia, and weight loss. Due to these potential adverse effects, its use in clinical practice has been largely discontinued.
History[edit]
Dextrothyroxine was developed in the mid-20th century as researchers sought alternatives to traditional lipid-lowering therapies. Despite its initial promise, the development of more effective and safer lipid-lowering agents, such as statins, has overshadowed its use.
