Peptide transporter 1: Difference between revisions
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'''Peptide | == Peptide Transporter 1 (PepT1) == | ||
[[File:PepT1.png|thumb|right|Diagram of Peptide Transporter 1 (PepT1) structure]] | |||
'''Peptide Transporter 1''' (PepT1) is a [[protein]] that plays a crucial role in the absorption of [[dipeptides]] and [[tripeptides]] from the [[small intestine]]. It is a member of the [[solute carrier family]] and is encoded by the SLC15A1 gene in humans. | |||
== Structure == | |||
PepT1 is an integral membrane protein that consists of 12 transmembrane domains. It is primarily located in the [[brush border]] membrane of the [[enterocytes]] in the small intestine. The structure of PepT1 allows it to transport small peptides across the cell membrane by utilizing a proton gradient. | |||
== Function == | == Function == | ||
== | PepT1 functions as a symporter, coupling the transport of peptides with protons (H+ ions). This mechanism is essential for the efficient absorption of dietary proteins, as it allows the uptake of peptides that are then further hydrolyzed into [[amino acids]] within the enterocytes. PepT1 is also involved in the absorption of certain [[peptide-based drugs]], making it a target for drug delivery research. | ||
== Regulation == | |||
The expression and activity of PepT1 are regulated by various factors, including dietary protein intake, hormones, and inflammatory mediators. For instance, high protein diets can upregulate PepT1 expression, enhancing peptide absorption. Conversely, inflammatory conditions such as [[inflammatory bowel disease]] can alter PepT1 function. | |||
== Clinical | == Clinical Significance == | ||
PepT1 has been implicated in several clinical conditions. Its role in drug absorption makes it a target for improving the bioavailability of peptide-based therapeutics. Additionally, alterations in PepT1 function or expression can contribute to malabsorption syndromes and other gastrointestinal disorders. | |||
== | == Related Pages == | ||
* [[Amino acid transporter]] | |||
* [ | * [[Brush border]] | ||
* [[Enterocyte]] | |||
* [[Protein digestion]] | |||
[[Category:Membrane | [[Category:Transport proteins]] | ||
[[Category:Membrane proteins]] | |||
[[Category:Human proteins]] | [[Category:Human proteins]] | ||
Latest revision as of 11:40, 15 February 2025
Peptide Transporter 1 (PepT1)[edit]
Peptide Transporter 1 (PepT1) is a protein that plays a crucial role in the absorption of dipeptides and tripeptides from the small intestine. It is a member of the solute carrier family and is encoded by the SLC15A1 gene in humans.
Structure[edit]
PepT1 is an integral membrane protein that consists of 12 transmembrane domains. It is primarily located in the brush border membrane of the enterocytes in the small intestine. The structure of PepT1 allows it to transport small peptides across the cell membrane by utilizing a proton gradient.
Function[edit]
PepT1 functions as a symporter, coupling the transport of peptides with protons (H+ ions). This mechanism is essential for the efficient absorption of dietary proteins, as it allows the uptake of peptides that are then further hydrolyzed into amino acids within the enterocytes. PepT1 is also involved in the absorption of certain peptide-based drugs, making it a target for drug delivery research.
Regulation[edit]
The expression and activity of PepT1 are regulated by various factors, including dietary protein intake, hormones, and inflammatory mediators. For instance, high protein diets can upregulate PepT1 expression, enhancing peptide absorption. Conversely, inflammatory conditions such as inflammatory bowel disease can alter PepT1 function.
Clinical Significance[edit]
PepT1 has been implicated in several clinical conditions. Its role in drug absorption makes it a target for improving the bioavailability of peptide-based therapeutics. Additionally, alterations in PepT1 function or expression can contribute to malabsorption syndromes and other gastrointestinal disorders.
