Tenocyclidine: Difference between revisions

Latest revision as of 11:38, 15 February 2025

An article about the dissociative anesthetic Tenocyclidine

Tenocyclidine[edit]

Tenocyclidine (TCP) is a dissociative anesthetic drug that was developed in the 1950s. It is chemically related to phencyclidine (PCP) and ketamine, and it acts primarily as an NMDA receptor antagonist.

Chemical structure and properties[edit]

Tenocyclidine is a member of the arylcyclohexylamine class of compounds. Its chemical structure consists of a cyclohexane ring bound to a piperidine ring and a phenyl group. The molecular formula of Tenocyclidine is C₁₆H₂₃N.

Pharmacology[edit]

Tenocyclidine acts as a non-competitive antagonist of the NMDA receptor, which is a subtype of glutamate receptor. By blocking the NMDA receptor, Tenocyclidine disrupts the normal excitatory neurotransmission in the brain, leading to its anesthetic and dissociative effects.

Effects[edit]

The effects of Tenocyclidine are similar to those of other dissociative anesthetics such as PCP and ketamine. These effects include:

Dissociation from the environment
Analgesia
Hallucinations
Euphoria
Altered perception of time and space

History[edit]

Tenocyclidine was first synthesized in the 1950s as part of research into new anesthetic agents. However, due to its potent psychoactive effects and potential for abuse, it was never marketed for medical use. It has been used in scientific research to study the effects of NMDA receptor antagonism.

Legal status[edit]

Due to its potential for abuse and lack of medical use, Tenocyclidine is classified as a controlled substance in many countries. It is listed as a Schedule I substance under the Controlled Substances Act in the United States, indicating that it is considered to have a high potential for abuse and no accepted medical use.

Related pages[edit]

@@ Line 1: / Line 1: @@
-'''Tenocyclidine''' (also known as '''TCP''') is a [[dissociative]] [[anesthetic]] drug with [[hallucinogenic]] effects. It is similar in effects to [[phencyclidine]] but is considerably more potent due to increased stimulation of the [[NMDA receptor]].
+{{Short description|An article about the dissociative anesthetic Tenocyclidine}}
-== History ==
+==Tenocyclidine==
+[[File:Tenocyclidine.svg|thumb|right|Chemical structure of Tenocyclidine]]
+'''Tenocyclidine''' (TCP) is a dissociative anesthetic drug that was developed in the 1950s. It is chemically related to [[phencyclidine]] (PCP) and [[ketamine]], and it acts primarily as an [[NMDA receptor antagonist]].
-Tenocyclidine was discovered in the 1950s during research into analogs of phencyclidine. It was found to be around 3-5 times more potent than PCP and was considered for medical use in humans due to its increased potency and lower dosage requirement, but its development was dropped due to the high incidence of [[dysphoria]] and [[psychosis]]-like side effects.
+==Chemical structure and properties==
+Tenocyclidine is a member of the [[arylcyclohexylamine]] class of compounds. Its chemical structure consists of a cyclohexane ring bound to a piperidine ring and a phenyl group. The molecular formula of Tenocyclidine is C<sub>16</sub>H<sub>23</sub>N.
-== Pharmacology ==
+==Pharmacology==
+Tenocyclidine acts as a non-competitive antagonist of the [[N-methyl-D-aspartate receptor|NMDA receptor]], which is a subtype of [[glutamate receptor]]. By blocking the NMDA receptor, Tenocyclidine disrupts the normal excitatory neurotransmission in the brain, leading to its anesthetic and dissociative effects.
-Like other [[dissociative]]s, tenocyclidine acts as an [[NMDA receptor antagonist]]. However, unlike most dissociatives, it also acts as a [[Dopamine reuptake inhibitor]], which may explain some of its stimulating effects.
+==Effects==
+The effects of Tenocyclidine are similar to those of other dissociative anesthetics such as PCP and ketamine. These effects include:
+* Dissociation from the environment
+* Analgesia
+* Hallucinations
+* Euphoria
+* Altered perception of time and space
-== Effects ==
+==History==
+Tenocyclidine was first synthesized in the 1950s as part of research into new anesthetic agents. However, due to its potent psychoactive effects and potential for abuse, it was never marketed for medical use. It has been used in scientific research to study the effects of NMDA receptor antagonism.
-The effects of tenocyclidine are similar to those of other [[dissociative]]s. Users may experience feelings of [[detachment]] or [[disconnection]] from their bodies and surroundings, as well as [[hallucinations]]. However, due to its potency, the risk of [[overdose]] and serious side effects is higher than with other dissociatives.
+==Legal status==
+Due to its potential for abuse and lack of medical use, Tenocyclidine is classified as a controlled substance in many countries. It is listed as a Schedule I substance under the [[Controlled Substances Act]] in the United States, indicating that it is considered to have a high potential for abuse and no accepted medical use.
-== Legal status ==
-Tenocyclidine is a [[Schedule I]] controlled substance in the United States, meaning it is illegal to manufacture, buy, possess, or distribute without a license from the [[Drug Enforcement Administration]].
-== See also ==
+==Related pages==
 * [[Phencyclidine]]
-* [[Dissociative]]
+* [[Ketamine]]
+* [[Dissociative anesthetic]]
 * [[NMDA receptor antagonist]]
-== References ==
+[[Category:Dissociative drugs]]
+[[Category:NMDA receptor antagonists]]
-<references />
+[[Category:Psychoactive drugs]]
-[[Category:Drugs]]
-[[Category:Anesthetics]]
-[[Category:Dissociatives]]
-[[Category:Hallucinogens]]
-[[Category:Controlled substances]]
-{{stub}}