WIN 54,461: Difference between revisions

Latest revision as of 11:32, 15 February 2025

Bromopravadoline[edit]

Chemical structure of 6-Bromopravadoline

Bromopravadoline is a synthetic compound that acts as a cannabinoid receptor agonist. It is primarily used in scientific research to study the endocannabinoid system and its effects on pain management, inflammation, and other physiological processes.

Chemical Properties[edit]

Bromopravadoline is a derivative of pravadoline, a nonsteroidal anti-inflammatory drug (NSAID) that was initially developed for its analgesic properties. The addition of a bromine atom to the pravadoline structure enhances its affinity for cannabinoid receptors, particularly the CB1 receptor.

Mechanism of Action[edit]

Bromopravadoline exerts its effects by binding to and activating cannabinoid receptors in the central nervous system and peripheral nervous system. This activation leads to the modulation of neurotransmitter release, resulting in analgesic and anti-inflammatory effects. The compound's action on the CB1 receptor is similar to that of endogenous cannabinoids like anandamide and 2-arachidonoylglycerol.

Pharmacological Effects[edit]

The primary effects of bromopravadoline include:

Analgesia: By activating cannabinoid receptors, bromopravadoline can reduce the perception of pain.
Anti-inflammatory effects: It can decrease inflammation by modulating immune cell activity.
Neuroprotection: Some studies suggest that bromopravadoline may have neuroprotective properties, potentially beneficial in conditions like neurodegenerative diseases.

Research Applications[edit]

Bromopravadoline is used in preclinical studies to explore the therapeutic potential of cannabinoid receptor agonists. It serves as a tool to understand the role of the endocannabinoid system in various physiological and pathological processes.

Safety and Toxicology[edit]

As with many research chemicals, the safety profile of bromopravadoline is not fully established. It is primarily used in controlled laboratory settings, and its effects in humans are not well-documented.

Related Pages[edit]

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-'''WIN 54,461''' is a [[chemical compound]] that belongs to the class of [[organic compounds]] known as [[pyrazoles]]. It is a synthetic compound that has been studied for its potential use in various scientific and medical applications.
+== Bromopravadoline ==
-==Chemical Structure==
+[[File:6-Bromopravadoline.svg|thumb|right|Chemical structure of 6-Bromopravadoline]]
-WIN 54,461 is a pyrazole derivative, which means it contains a [[pyrazole]] ring in its structure. Pyrazoles are five-membered aromatic rings that contain three carbon atoms and two nitrogen atoms. The specific structure of WIN 54,461 includes additional functional groups that give it its unique properties.
-==Synthesis==
+'''Bromopravadoline''' is a synthetic compound that acts as a [[cannabinoid receptor]] agonist. It is primarily used in scientific research to study the [[endocannabinoid system]] and its effects on [[pain management]], [[inflammation]], and other physiological processes.
-The synthesis of WIN 54,461 involves several steps, starting with the formation of the pyrazole ring. This is typically achieved through the reaction of a [[diazonium compound]] with a [[ketone]] or [[aldehyde]]. The resulting pyrazole is then further modified to produce the final WIN 54,461 compound.
-==Potential Applications==
+== Chemical Properties ==
-While WIN 54,461 is primarily used for research purposes, it has been studied for its potential use in various applications. For example, due to its structure and properties, it has been investigated as a potential [[ligand]] for various [[receptor]] types in the body. However, more research is needed to fully understand its potential uses and effects.
-==Safety and Toxicity==
+Bromopravadoline is a derivative of [[pravadoline]], a nonsteroidal anti-inflammatory drug (NSAID) that was initially developed for its analgesic properties. The addition of a bromine atom to the pravadoline structure enhances its affinity for cannabinoid receptors, particularly the [[CB1 receptor]].
-As with any chemical compound, the safety and toxicity of WIN 54,461 are important considerations. While specific data on this compound may not be readily available, general safety practices for handling chemical compounds should be followed. This includes using appropriate personal protective equipment and following safe handling and disposal procedures.
-==See Also==
+== Mechanism of Action ==
-* [[Pyrazole]]
-* [[Organic compound]]
-* [[Chemical synthesis]]
-[[Category:Chemical compounds]]
+Bromopravadoline exerts its effects by binding to and activating cannabinoid receptors in the [[central nervous system]] and [[peripheral nervous system]]. This activation leads to the modulation of neurotransmitter release, resulting in analgesic and anti-inflammatory effects. The compound's action on the CB1 receptor is similar to that of endogenous cannabinoids like [[anandamide]] and [[2-arachidonoylglycerol]].
-[[Category:Organic compounds]]
-[[Category:Pyrazoles]]
-{{Chem-stub}}
+== Pharmacological Effects ==
+The primary effects of bromopravadoline include:
+* '''Analgesia''': By activating cannabinoid receptors, bromopravadoline can reduce the perception of pain.
+* '''Anti-inflammatory effects''': It can decrease inflammation by modulating immune cell activity.
+* '''Neuroprotection''': Some studies suggest that bromopravadoline may have neuroprotective properties, potentially beneficial in conditions like [[neurodegenerative diseases]].
+== Research Applications ==
+Bromopravadoline is used in preclinical studies to explore the therapeutic potential of cannabinoid receptor agonists. It serves as a tool to understand the role of the endocannabinoid system in various physiological and pathological processes.
+== Safety and Toxicology ==
+As with many research chemicals, the safety profile of bromopravadoline is not fully established. It is primarily used in controlled laboratory settings, and its effects in humans are not well-documented.
+== Related Pages ==
+* [[Cannabinoid receptor]]
+* [[Endocannabinoid system]]
+* [[Pravadoline]]
+* [[Analgesic]]
+* [[Nonsteroidal anti-inflammatory drug]]
+[[Category:Cannabinoids]]
+[[Category:Research chemicals]]