Sulfafurazole: Difference between revisions

Latest revision as of 11:04, 15 February 2025

Sulfafurazole[edit]

Sulfafurazole, also known as sulfisoxazole, is a sulfonamide antibiotic used to treat a variety of bacterial infections. It is part of the sulfonamide class of drugs, which are synthetic antimicrobial agents that contain the sulfonamide group. Sulfafurazole is effective against a broad spectrum of Gram-positive and Gram-negative bacteria.

Mechanism of Action[edit]

Sulfafurazole works by inhibiting the bacterial enzyme dihydropteroate synthase, which is involved in the synthesis of folic acid. Bacteria require folic acid for the synthesis of nucleic acids, which are essential for DNA replication and cell division. By blocking this pathway, sulfafurazole prevents bacterial growth and multiplication, acting as a bacteriostatic agent.

Clinical Uses[edit]

Sulfafurazole is used to treat a variety of infections, including:

It is often used in combination with other antibiotics to enhance its effectiveness and reduce the risk of resistance.

Side Effects[edit]

Common side effects of sulfafurazole include:

Serious side effects can include:

Patients with a known allergy to sulfonamides should avoid using sulfafurazole.

Pharmacokinetics[edit]

Sulfafurazole is well absorbed from the gastrointestinal tract and is widely distributed throughout the body. It is metabolized in the liver and excreted primarily in the urine. The drug has a half-life of approximately 6 to 12 hours, allowing for multiple daily dosing.

Related Pages[edit]

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-'''Stay sutures''' are a type of [[suture]] used in [[surgery]] to hold an incision or wound open while the surgeon works. They are typically removed after the procedure is completed. Stay sutures are particularly useful in procedures where the surgeon needs to maintain a clear view of the surgical field, such as in [[abdominal surgery]] or [[thoracic surgery]].
+== Sulfafurazole ==
-== Usage ==
+[[File:Sulfafurazole.svg|thumb|right|Chemical structure of Sulfafurazole]]
-Stay sutures are used in a variety of surgical procedures. They are often used in [[abdominal surgery]] to hold the abdominal wall open, allowing the surgeon to have a clear view of the internal organs. In [[thoracic surgery]], stay sutures may be used to hold the ribs apart, providing access to the lungs or heart.
+'''Sulfafurazole''', also known as '''sulfisoxazole''', is a [[sulfonamide]] [[antibiotic]] used to treat a variety of [[bacterial infections]]. It is part of the [[sulfonamide class]] of drugs, which are synthetic antimicrobial agents that contain the sulfonamide group. Sulfafurazole is effective against a broad spectrum of [[Gram-positive]] and [[Gram-negative bacteria]].
-Stay sutures can also be used in [[microsurgery]] to hold small blood vessels or nerves in place while they are being repaired. They can also be used in [[ophthalmic surgery]] to hold the eyelids open.
+== Mechanism of Action ==
-== Types ==
+Sulfafurazole works by inhibiting the bacterial enzyme [[dihydropteroate synthase]], which is involved in the synthesis of [[folic acid]]. Bacteria require folic acid for the synthesis of [[nucleic acids]], which are essential for [[DNA replication]] and [[cell division]]. By blocking this pathway, sulfafurazole prevents bacterial growth and multiplication, acting as a [[bacteriostatic]] agent.
-There are several types of stay sutures, including:
+== Clinical Uses ==
-* '''[[Silk sutures]]''': These are often used because they are strong and easy to handle. However, they can cause inflammation and are not absorbed by the body.
+Sulfafurazole is used to treat a variety of infections, including:
-* '''[[Polypropylene sutures]]''': These are non-absorbable and cause less inflammation than silk sutures. They are often used in cardiovascular and ophthalmic surgery.
-* '''[[Polydioxanone sutures]]''': These are absorbable and cause less inflammation than silk sutures. They are often used in pediatric surgery.
-== Complications ==
+* [[Urinary tract infections]]
+* [[Respiratory tract infections]]
+* [[Otitis media]]
+* [[Meningitis]]
-While stay sutures are generally safe, complications can occur. These may include [[infection]], [[hematoma]], [[seroma]], and [[wound dehiscence]]. In rare cases, a stay suture may break or become dislodged, requiring additional surgery to repair.
+It is often used in combination with other antibiotics to enhance its effectiveness and reduce the risk of resistance.
-== See also ==
+== Side Effects ==
-* [[Suture (surgery)]]
+Common side effects of sulfafurazole include:
-* [[Surgical suture]]
-* [[List of surgical procedures]]
-[[Category:Medical terminology]]
+* [[Nausea]]
-[[Category:Surgical procedures]]
+* [[Vomiting]]
-[[Category:Surgical suture]]
+* [[Diarrhea]]
+* [[Rash]]
-{{stub}}
+Serious side effects can include:
+* [[Stevens-Johnson syndrome]]
+* [[Agranulocytosis]]
+* [[Aplastic anemia]]
+Patients with a known allergy to sulfonamides should avoid using sulfafurazole.
+== Pharmacokinetics ==
+Sulfafurazole is well absorbed from the [[gastrointestinal tract]] and is widely distributed throughout the body. It is metabolized in the [[liver]] and excreted primarily in the [[urine]]. The drug has a half-life of approximately 6 to 12 hours, allowing for multiple daily dosing.
+== Related Pages ==
+* [[Sulfonamide (medicine)]]
+* [[Antibiotic]]
+* [[Bacterial resistance]]
+[[Category:Antibiotics]]
+[[Category:Sulfonamides]]