Burapitant: Difference between revisions

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'''Burapitant''' is a [[drug]] used in the field of [[medicine]] for the treatment of [[chemotherapy]]-induced [[nausea]] and [[vomiting]]. It is classified as a [[neurokinin 1 receptor antagonist]], which means it works by blocking the action of a chemical in the brain that triggers nausea and vomiting.
{{DISPLAYTITLE:Burapitant}}


==Pharmacology==
==Overview==
Burapitant is a highly selective and potent neurokinin 1 receptor antagonist. It works by blocking the action of [[substance P]], a neurotransmitter in the brain that plays a key role in the vomiting reflex. By inhibiting the binding of substance P to its receptor, burapitant can prevent nausea and vomiting.
'''Burapitant''' is a chemical compound that acts as a [[neurokinin-1 receptor antagonist]]. It is primarily researched for its potential use in treating conditions such as [[nausea]] and [[vomiting]], particularly those induced by [[chemotherapy]].


==Clinical Use==
==Chemical Structure==
Burapitant is used in combination with other antiemetic medications for the prevention of acute and delayed nausea and vomiting associated with highly emetogenic and moderately emetogenic cancer chemotherapy. It is administered orally in the form of a capsule.
[[File:Burapitant_structure.png|thumb|right|Chemical structure of Burapitant]]
Burapitant is characterized by its unique chemical structure, which allows it to effectively bind to and inhibit the [[neurokinin-1 receptor]]. This receptor is involved in the body's response to stress and pain, making Burapitant a compound of interest in the development of new therapeutic agents.


==Side Effects==
==Mechanism of Action==
Like all medications, burapitant can cause side effects. The most common side effects include [[fatigue]], [[constipation]], and [[diarrhea]]. Less common side effects can include [[dizziness]], [[headache]], and [[abdominal pain]].  
Burapitant works by blocking the action of [[substance P]], a neuropeptide that binds to the neurokinin-1 receptor. By inhibiting this interaction, Burapitant can reduce the symptoms associated with [[emesis]] and potentially other conditions mediated by substance P.


==Contraindications==
==Potential Applications==
Burapitant should not be used in patients with known hypersensitivity to the drug or any of its components. It should also be used with caution in patients with severe hepatic impairment, as the drug is extensively metabolized in the liver.
The primary application of Burapitant is in the management of [[chemotherapy-induced nausea and vomiting]] (CINV). It may also have potential uses in treating other conditions where substance P is implicated, such as certain types of [[pain]] and [[depression]].


==See Also==
==Research and Development==
* [[Chemotherapy]]
Research into Burapitant is ongoing, with studies focusing on its efficacy, safety, and potential side effects. As a neurokinin-1 receptor antagonist, it is part of a class of drugs that are being explored for their ability to improve the quality of life for patients undergoing [[cancer treatment]].
* [[Nausea]]
 
* [[Vomiting]]
==Related pages==
* [[Neurokinin 1 receptor antagonist]]
* [[Neurokinin-1 receptor antagonist]]
* [[Chemotherapy-induced nausea and vomiting]]
* [[Substance P]]
* [[Substance P]]


[[Category:Drugs]]
[[Category:Medicine]]
[[Category:Pharmacology]]
[[Category:Pharmacology]]
[[Category:Chemotherapy]]
[[Category:Antiemetics]]
[[Category:Nausea]]
[[Category:Vomiting]]
 
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Latest revision as of 11:00, 15 February 2025


Overview[edit]

Burapitant is a chemical compound that acts as a neurokinin-1 receptor antagonist. It is primarily researched for its potential use in treating conditions such as nausea and vomiting, particularly those induced by chemotherapy.

Chemical Structure[edit]

Chemical structure of Burapitant

Burapitant is characterized by its unique chemical structure, which allows it to effectively bind to and inhibit the neurokinin-1 receptor. This receptor is involved in the body's response to stress and pain, making Burapitant a compound of interest in the development of new therapeutic agents.

Mechanism of Action[edit]

Burapitant works by blocking the action of substance P, a neuropeptide that binds to the neurokinin-1 receptor. By inhibiting this interaction, Burapitant can reduce the symptoms associated with emesis and potentially other conditions mediated by substance P.

Potential Applications[edit]

The primary application of Burapitant is in the management of chemotherapy-induced nausea and vomiting (CINV). It may also have potential uses in treating other conditions where substance P is implicated, such as certain types of pain and depression.

Research and Development[edit]

Research into Burapitant is ongoing, with studies focusing on its efficacy, safety, and potential side effects. As a neurokinin-1 receptor antagonist, it is part of a class of drugs that are being explored for their ability to improve the quality of life for patients undergoing cancer treatment.

Related pages[edit]