Nucleoside-diphosphatase: Difference between revisions
CSV import Tags: mobile edit mobile web edit |
CSV import |
||
| Line 1: | Line 1: | ||
'''Nucleoside-diphosphatase''' is an | {{DISPLAYTITLE:Nucleoside-diphosphatase}} | ||
== Nucleoside-diphosphatase == | |||
[[File:2h2n.jpg|thumb|right|Structure of Nucleoside-diphosphatase]] | |||
'''Nucleoside-diphosphatase''' (NDPase) is an enzyme that catalyzes the hydrolysis of nucleoside diphosphates into nucleoside monophosphates and inorganic phosphate. This enzyme plays a crucial role in nucleotide metabolism and is involved in various cellular processes, including [[DNA replication]], [[RNA synthesis]], and [[cell signaling]]. | |||
== Function == | == Function == | ||
Nucleoside-diphosphatase is responsible for the conversion of nucleoside diphosphates (NDPs) to nucleoside monophosphates (NMPs) by removing a phosphate group. This reaction is important for maintaining the balance of nucleotides within the cell and for the recycling of nucleotides during nucleic acid metabolism. | |||
== Mechanism == | |||
The enzyme operates by binding to the nucleoside diphosphate substrate and facilitating the cleavage of the phosphoanhydride bond. This process involves the coordination of a water molecule, which acts as a nucleophile to attack the phosphorus atom, leading to the release of inorganic phosphate and the formation of a nucleoside monophosphate. | |||
== Structure == | == Structure == | ||
Nucleoside-diphosphatases are typically composed of a single polypeptide chain that folds into a specific three-dimensional structure necessary for its enzymatic activity. The active site of the enzyme is usually located in a cleft or pocket that accommodates the substrate and facilitates the catalytic reaction. | |||
== Biological Importance == | |||
Nucleoside-diphosphatases are essential for the proper functioning of cellular processes that require nucleotides. They are involved in the regulation of nucleotide pools, which is critical for [[DNA repair]], [[cell division]], and [[signal transduction]]. | |||
== Related Enzymes == | |||
Nucleoside-diphosphatase is part of a larger family of enzymes known as [[nucleotidases]], which are responsible for the hydrolysis of nucleotides. Other related enzymes include [[nucleoside-triphosphatase]] and [[nucleoside-monophosphatase]], which act on different substrates within the nucleotide metabolism pathway. | |||
== Related pages == | |||
* [[Nucleotide metabolism]] | |||
* [[Enzyme kinetics]] | |||
* [[Phosphatase]] | |||
* [[Nucleoside]] | * [[Nucleoside]] | ||
[[Category:Enzymes]] | [[Category:Enzymes]] | ||
[[Category: | [[Category:Nucleotide metabolism]] | ||
Latest revision as of 10:59, 15 February 2025
Nucleoside-diphosphatase[edit]
Nucleoside-diphosphatase (NDPase) is an enzyme that catalyzes the hydrolysis of nucleoside diphosphates into nucleoside monophosphates and inorganic phosphate. This enzyme plays a crucial role in nucleotide metabolism and is involved in various cellular processes, including DNA replication, RNA synthesis, and cell signaling.
Function[edit]
Nucleoside-diphosphatase is responsible for the conversion of nucleoside diphosphates (NDPs) to nucleoside monophosphates (NMPs) by removing a phosphate group. This reaction is important for maintaining the balance of nucleotides within the cell and for the recycling of nucleotides during nucleic acid metabolism.
Mechanism[edit]
The enzyme operates by binding to the nucleoside diphosphate substrate and facilitating the cleavage of the phosphoanhydride bond. This process involves the coordination of a water molecule, which acts as a nucleophile to attack the phosphorus atom, leading to the release of inorganic phosphate and the formation of a nucleoside monophosphate.
Structure[edit]
Nucleoside-diphosphatases are typically composed of a single polypeptide chain that folds into a specific three-dimensional structure necessary for its enzymatic activity. The active site of the enzyme is usually located in a cleft or pocket that accommodates the substrate and facilitates the catalytic reaction.
Biological Importance[edit]
Nucleoside-diphosphatases are essential for the proper functioning of cellular processes that require nucleotides. They are involved in the regulation of nucleotide pools, which is critical for DNA repair, cell division, and signal transduction.
Related Enzymes[edit]
Nucleoside-diphosphatase is part of a larger family of enzymes known as nucleotidases, which are responsible for the hydrolysis of nucleotides. Other related enzymes include nucleoside-triphosphatase and nucleoside-monophosphatase, which act on different substrates within the nucleotide metabolism pathway.
