Aglepristone: Difference between revisions
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'''Aglepristone''' is a synthetic steroid with antiprogestational | '''Aglepristone''' is a synthetic steroid with antiprogestational properties, primarily used in veterinary medicine. It is a [[progesterone receptor]] antagonist, which means it blocks the effects of progesterone, a hormone crucial for maintaining pregnancy in mammals. | ||
==Mechanism of Action== | ==Mechanism of Action== | ||
Aglepristone | Aglepristone works by binding to the progesterone receptors in the body, preventing progesterone from exerting its effects. This action leads to the termination of pregnancy in animals, as progesterone is essential for the maintenance of the uterine lining and the continuation of pregnancy. | ||
==Uses in Veterinary Medicine== | ==Uses in Veterinary Medicine== | ||
Aglepristone is used in | Aglepristone is commonly used in veterinary practice for the following purposes: | ||
* | |||
* | * '''Pregnancy termination''': It is used to induce abortion in dogs and cats when an unwanted pregnancy occurs. | ||
* | * '''Pyometra treatment''': Aglepristone can be used to treat [[pyometra]], a uterine infection in female dogs, by promoting the expulsion of infected uterine contents. | ||
* '''Management of reproductive disorders''': It is also used in the management of other reproductive disorders where progesterone plays a role. | |||
==Administration and Dosage== | ==Administration and Dosage== | ||
Aglepristone is administered via | Aglepristone is administered via subcutaneous injection. The dosage and frequency depend on the specific condition being treated and the species of the animal. It is important for veterinarians to follow the recommended guidelines to ensure efficacy and safety. | ||
==Side Effects== | ==Side Effects== | ||
Some common side effects of aglepristone include: | |||
* Local reactions at the injection site | |||
* | * Local reactions at the injection site, such as swelling or pain. | ||
* Mild gastrointestinal disturbances, such as vomiting or diarrhea. | |||
Serious side effects are rare but can occur, and it is important for veterinarians to monitor animals closely after administration. | |||
== | ==Contraindications== | ||
Aglepristone should be used | Aglepristone should not be used in animals with known hypersensitivity to the drug. It is also contraindicated in animals with certain health conditions where the use of a progesterone antagonist could be harmful. | ||
==Related | ==Image Gallery== | ||
[[File:Aglepristone.png|thumb|right|Chemical structure of Aglepristone]] | |||
==Related Pages== | |||
* [[Progesterone receptor]] | * [[Progesterone receptor]] | ||
* [[Pyometra]] | * [[Pyometra]] | ||
* [[Veterinary medicine]] | |||
[[Category:Veterinary drugs]] | [[Category:Veterinary drugs]] | ||
[[Category:Steroids]] | [[Category:Steroids]] | ||
Latest revision as of 04:02, 13 February 2025
A synthetic steroid used in veterinary medicine
Aglepristone is a synthetic steroid with antiprogestational properties, primarily used in veterinary medicine. It is a progesterone receptor antagonist, which means it blocks the effects of progesterone, a hormone crucial for maintaining pregnancy in mammals.
Mechanism of Action[edit]
Aglepristone works by binding to the progesterone receptors in the body, preventing progesterone from exerting its effects. This action leads to the termination of pregnancy in animals, as progesterone is essential for the maintenance of the uterine lining and the continuation of pregnancy.
Uses in Veterinary Medicine[edit]
Aglepristone is commonly used in veterinary practice for the following purposes:
- Pregnancy termination: It is used to induce abortion in dogs and cats when an unwanted pregnancy occurs.
- Pyometra treatment: Aglepristone can be used to treat pyometra, a uterine infection in female dogs, by promoting the expulsion of infected uterine contents.
- Management of reproductive disorders: It is also used in the management of other reproductive disorders where progesterone plays a role.
Administration and Dosage[edit]
Aglepristone is administered via subcutaneous injection. The dosage and frequency depend on the specific condition being treated and the species of the animal. It is important for veterinarians to follow the recommended guidelines to ensure efficacy and safety.
Side Effects[edit]
Some common side effects of aglepristone include:
- Local reactions at the injection site, such as swelling or pain.
- Mild gastrointestinal disturbances, such as vomiting or diarrhea.
Serious side effects are rare but can occur, and it is important for veterinarians to monitor animals closely after administration.
Contraindications[edit]
Aglepristone should not be used in animals with known hypersensitivity to the drug. It is also contraindicated in animals with certain health conditions where the use of a progesterone antagonist could be harmful.
Image Gallery[edit]
