WAY-166818: Difference between revisions

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'''WAY-166818''' is a [[nonsteroidal]] [[antagonist]] of the [[androgen receptor]] (AR) that was never marketed. It is selective for the AR over other [[steroid hormone receptor]]s and has been used to elucidate the role of the AR in [[bone]] and [[muscle]] physiology in scientific research.
{{DISPLAYTITLE:WAY-166818}}


==Pharmacology==
== Overview ==
WAY-166818 is a nonsteroidal antagonist of the AR, the biological target of [[androgen]]s like [[testosterone]] and [[dihydrotestosterone]] (DHT). It has been found to block the effects of these androgens in [[bioassay]]s and has been used in scientific research to elucidate the role of the AR in bone and muscle physiology.
'''WAY-166818''' is a chemical compound that has been studied for its potential effects on the [[central nervous system]]. It is classified as a [[pharmacological agent]] and has been the subject of research in the context of [[neuropharmacology]].


==Chemistry==
== Chemical Structure ==
WAY-166818, also known as 4-[7-[[2-(4-Methylphenyl)-5,7-dimethyl-2,3-dihydro-1H-pyrrolizin-1-yl]methyl]-2,3-dihydro-1H-pyrrolizin-1-yl]-2-methylbenzonitrile, is a synthetic compound of the [[pyrrolizine]] class. It is structurally related to the nonsteroidal AR antagonist [[bicalutamide]], which is used clinically as an [[antiandrogen]] in the treatment of [[prostate cancer]].
[[File:WAY-166818.svg|thumb|right|Chemical structure of WAY-166818]]
WAY-166818 is characterized by its unique chemical structure, which is depicted in the image to the right. The structure of WAY-166818 includes several functional groups that are of interest in the study of its pharmacological properties.


==Research==
== Mechanism of Action ==
Research with WAY-166818 has helped to elucidate the role of the AR in bone and muscle physiology. For instance, it has been found that the AR is essential for the maintenance of bone and muscle mass in males, and that androgens and the AR have important roles in the regulation of [[body composition]], [[muscle mass]], and [[bone density]].
WAY-166818 is believed to interact with specific [[receptors]] in the brain, influencing [[neurotransmitter]] activity. The exact mechanism of action is still under investigation, but it is thought to modulate the activity of certain [[neurotransmitter systems]], potentially affecting [[mood]], [[cognition]], and [[behavior]].


==See also==
== Potential Applications ==
* [[List of investigational sex-hormonal agents]]
Research into WAY-166818 has explored its potential use in treating various [[neurological disorders]]. It has been studied for its effects on conditions such as [[anxiety]], [[depression]], and other mood disorders. The compound's ability to influence neurotransmitter systems makes it a candidate for further investigation in the development of new [[therapeutic agents]].
* [[List of androgen receptor antagonists]]


==References==
== Safety and Efficacy ==
<references />
The safety and efficacy of WAY-166818 are subjects of ongoing research. Initial studies have provided insights into its pharmacokinetic properties and potential side effects. However, more comprehensive clinical trials are necessary to fully understand its therapeutic potential and safety profile.


==External links==
== Related Pages ==
* [https://pubchem.ncbi.nlm.nih.gov/compound/WAY-166818 PubChem Compound Summary for CID 9794143, WAY-166818]
* [[Neuropharmacology]]
* [[Central nervous system]]
* [[Neurotransmitter]]
* [[Pharmacological agent]]


[[Category:Androgen receptor antagonists]]
[[Category:Pharmacology]]
[[Category:Nonsteroidal antiandrogens]]
[[Category:Neuropharmacology]]
[[Category:Pyrrolizines]]
[[Category:Abandoned drugs]]
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Latest revision as of 04:01, 13 February 2025


Overview[edit]

WAY-166818 is a chemical compound that has been studied for its potential effects on the central nervous system. It is classified as a pharmacological agent and has been the subject of research in the context of neuropharmacology.

Chemical Structure[edit]

File:WAY-166818.svg
Chemical structure of WAY-166818

WAY-166818 is characterized by its unique chemical structure, which is depicted in the image to the right. The structure of WAY-166818 includes several functional groups that are of interest in the study of its pharmacological properties.

Mechanism of Action[edit]

WAY-166818 is believed to interact with specific receptors in the brain, influencing neurotransmitter activity. The exact mechanism of action is still under investigation, but it is thought to modulate the activity of certain neurotransmitter systems, potentially affecting mood, cognition, and behavior.

Potential Applications[edit]

Research into WAY-166818 has explored its potential use in treating various neurological disorders. It has been studied for its effects on conditions such as anxiety, depression, and other mood disorders. The compound's ability to influence neurotransmitter systems makes it a candidate for further investigation in the development of new therapeutic agents.

Safety and Efficacy[edit]

The safety and efficacy of WAY-166818 are subjects of ongoing research. Initial studies have provided insights into its pharmacokinetic properties and potential side effects. However, more comprehensive clinical trials are necessary to fully understand its therapeutic potential and safety profile.

Related Pages[edit]