CBiPES: Difference between revisions

Latest revision as of 03:44, 13 February 2025

Overview[edit]

CBiPES is a chemical compound that acts as a selective positive allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGluR5). It is primarily used in scientific research to study the role of mGluR5 in various physiological and pathological processes.

Chemical Properties[edit]

CBiPES is characterized by its unique chemical structure, which allows it to bind to the allosteric site of the mGluR5 receptor. This binding enhances the receptor's response to its natural ligand, glutamate, without directly activating the receptor itself.

Mechanism of Action[edit]

CBiPES functions by modulating the activity of mGluR5 receptors. As a positive allosteric modulator, it increases the efficacy of glutamate binding, thereby potentiating the receptor's signaling pathways. This modulation can influence various neurotransmission processes in the central nervous system.

Research Applications[edit]

CBiPES is utilized in research to explore the therapeutic potential of mGluR5 modulation in treating neurological and psychiatric disorders. Studies have investigated its effects in models of schizophrenia, anxiety, and Parkinson's disease.

Related Compounds[edit]

CBiPES is part of a broader class of compounds known as allosteric modulators. Other related compounds include MPEP and ADX-47273, which also target mGluR5 but with different modulatory effects.

Related Pages[edit]

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-'''CBiPES''' is a chemical compound that is often used in scientific research. It is a cell-permeable inhibitor of [[TRIP-Br1]], a transcriptional regulator implicated in cell cycle progression and [[apoptosis]].
+{{DISPLAYTITLE:CBiPES}}
-==Chemical Structure==
+== Overview ==
-CBiPES has a molecular formula of C20H23N3O2S and a molecular weight of 365.48 g/mol. Its systematic name is N-(cyclohexylmethyl)-4-(2-phenylethynyl)benzenesulfonamide. The compound is typically available as a white to off-white powder.
+[[File:CBiPES_Structure.svg|thumb|right|Chemical structure of CBiPES]]
+'''CBiPES''' is a chemical compound that acts as a selective positive allosteric modulator of the [[metabotropic glutamate receptor]] subtype 5 (mGluR5). It is primarily used in scientific research to study the role of mGluR5 in various physiological and pathological processes.
-==Mechanism of Action==
+== Chemical Properties ==
-CBiPES acts by binding to the [[transcriptional regulator]] TRIP-Br1, thereby inhibiting its function. TRIP-Br1 is known to interact with various proteins involved in cell cycle progression and apoptosis, including [[cyclin E]], [[CDK2]], and [[p53]]. By inhibiting TRIP-Br1, CBiPES can affect these processes and potentially influence cell growth and survival.
+CBiPES is characterized by its unique chemical structure, which allows it to bind to the allosteric site of the mGluR5 receptor. This binding enhances the receptor's response to its natural ligand, [[glutamate]], without directly activating the receptor itself.
-==Applications in Research==
+== Mechanism of Action ==
-CBiPES has been used in various research studies to investigate the role of TRIP-Br1 in cell cycle regulation and apoptosis. For example, it has been used to study the effects of TRIP-Br1 inhibition on cancer cell growth and survival. In addition, CBiPES has been used to investigate the potential therapeutic applications of TRIP-Br1 inhibition in cancer treatment.
+CBiPES functions by modulating the activity of mGluR5 receptors. As a positive allosteric modulator, it increases the efficacy of glutamate binding, thereby potentiating the receptor's signaling pathways. This modulation can influence various [[neurotransmission]] processes in the [[central nervous system]].
-==Safety and Handling==
+== Research Applications ==
-As with all chemical compounds, CBiPES should be handled with care. It should be stored in a cool, dry place and protected from light. Direct contact with the skin or eyes should be avoided, and appropriate personal protective equipment should be worn when handling this compound.
+CBiPES is utilized in research to explore the therapeutic potential of mGluR5 modulation in treating neurological and psychiatric disorders. Studies have investigated its effects in models of [[schizophrenia]], [[anxiety]], and [[Parkinson's disease]].
-==References==
+== Related Compounds ==
-* ''TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1''. Embo J. 2001 May 1;20(9):2273-85.
+CBiPES is part of a broader class of compounds known as allosteric modulators. Other related compounds include [[MPEP]] and [[ADX-47273]], which also target mGluR5 but with different modulatory effects.
-* ''A small molecule inhibitor of TRIP-Br1 down-regulates cyclin E and inhibits cancer cell proliferation''. Cancer Lett. 2011 Jan 28;300(2):145-53.
-[[Category:Chemical compounds]]
+== Related Pages ==
-[[Category:Research chemicals]]
+* [[Metabotropic glutamate receptor]]
-[[Category:Cell biology]]
+* [[Allosteric modulator]]
-{{Chemistry-stub}}
+* [[Neurotransmission]]
-{{medicine-stub}}
-{{No image}}
+[[Category:Pharmacology]]
+[[Category:Neuroscience]]