Ki Database: Difference between revisions

Latest revision as of 03:30, 13 February 2025

Ki Database[edit]

Logo of the Psychoactive Drug Screening Program

The Ki Database is a comprehensive resource that provides information on the binding affinities of various ligands to a wide range of receptors, transporters, and ion channels. It is an essential tool for researchers in the fields of pharmacology, neuroscience, and drug discovery. The database is maintained by the Psychoactive Drug Screening Program (PDSP) at the University of North Carolina at Chapel Hill.

Overview[edit]

The Ki Database contains data on the inhibitory constant, or Ki, which is a measure of how effectively a compound can inhibit a particular biological target. The lower the Ki value, the higher the affinity of the compound for the target. This information is crucial for understanding the potential efficacy and selectivity of drugs.

Data Collection[edit]

Data in the Ki Database is collected from a variety of sources, including published scientific literature and experimental results from the PDSP. The database is regularly updated to include new findings and to ensure the accuracy of the information provided.

Applications[edit]

The Ki Database is widely used in the development of new pharmaceuticals. By providing detailed information on the binding properties of compounds, researchers can identify promising drug candidates and optimize their chemical structures for better efficacy and safety. The database also aids in the study of receptor function and the development of therapeutic agents for various diseases.

Access and Usage[edit]

The Ki Database is accessible online and is freely available to the scientific community. Users can search for specific compounds or targets, and the database provides detailed reports on the binding affinities and related pharmacological data.

Related Pages[edit]

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-'''Ki Database''' is a comprehensive [[database]] that contains information about the binding affinity of drugs and other chemical substances to various [[protein]] targets in the body. The database is an essential tool for [[pharmacology]] and [[drug discovery]] research, as it provides valuable insights into the interactions between drugs and their targets.
+== Ki Database ==
+[[File:PDSPLogo.jpg|thumb|right|Logo of the Psychoactive Drug Screening Program]]
+The '''Ki Database''' is a comprehensive resource that provides information on the binding affinities of various ligands to a wide range of receptors, transporters, and ion channels. It is an essential tool for researchers in the fields of [[pharmacology]], [[neuroscience]], and [[drug discovery]]. The database is maintained by the [[Psychoactive Drug Screening Program]] (PDSP) at the [[University of North Carolina at Chapel Hill]].
 == Overview ==
-The Ki Database is a collection of data on the binding affinity, or Ki, of drugs and other chemical substances to various protein targets. The Ki value is a measure of how strongly a substance binds to a protein, and is a key parameter in pharmacology and drug discovery. The database contains data on thousands of substances and their targets, and is regularly updated with new data from scientific research.
+The Ki Database contains data on the inhibitory constant, or Ki, which is a measure of how effectively a compound can inhibit a particular biological target. The lower the Ki value, the higher the affinity of the compound for the target. This information is crucial for understanding the potential efficacy and selectivity of drugs.
-== Use in Pharmacology ==
+== Data Collection ==
-In pharmacology, the Ki Database is used to study the interactions between drugs and their targets. By analyzing the Ki values of different substances, researchers can gain insights into how drugs interact with their targets, and how these interactions affect the drug's efficacy and side effects. This information can be used to design more effective and safer drugs.
+Data in the Ki Database is collected from a variety of sources, including published scientific literature and experimental results from the PDSP. The database is regularly updated to include new findings and to ensure the accuracy of the information provided.
-== Use in Drug Discovery ==
+== Applications ==
-In drug discovery, the Ki Database is used to identify potential new drug targets. By analyzing the Ki values of different substances, researchers can identify proteins that are strongly bound by certain substances. These proteins can then be investigated as potential targets for new drugs.
+The Ki Database is widely used in the development of new [[pharmaceuticals]]. By providing detailed information on the binding properties of compounds, researchers can identify promising drug candidates and optimize their chemical structures for better efficacy and safety. The database also aids in the study of [[receptor]] function and the development of [[therapeutic agents]] for various diseases.
-== Accessing the Ki Database ==
+== Access and Usage ==
-The Ki Database is freely accessible online, and can be searched by substance name, protein target, or Ki value. The database also provides tools for analyzing and visualizing the data, making it a valuable resource for researchers in pharmacology and drug discovery.
+The Ki Database is accessible online and is freely available to the scientific community. Users can search for specific compounds or targets, and the database provides detailed reports on the binding affinities and related pharmacological data.
-== See Also ==
+== Related Pages ==
 * [[Pharmacology]]
-* [[Drug Discovery]]
+* [[Receptor (biochemistry)]]
-* [[Protein Target]]
+* [[Drug discovery]]
-* [[Binding Affinity]]
+* [[Neuroscience]]
 [[Category:Pharmacology]]
-[[Category:Drug Discovery]]
+[[Category:Databases]]
-[[Category:Bioinformatics Databases]]
+[[Category:Neuroscience]]
-{{pharmacology-stub}}