Pseudovirus (genus)

Pseudovirus is a genus of viruses in the order Mononegavirales, and family Filoviridae. Viruses in Pseudovirus genus are enveloped, with filamentous geometries. The viruses' genomes are non-segmented, negative-sense, single-stranded RNA.

Structure and Genome

Pseudoviruses are enveloped, with filamentous geometries. The diameter is around 80 nm. Genomes are linear, around 19 kb in length. The genome codes for 7 proteins.

Life Cycle

Viral replication is cytoplasmic. Entry into the host cell is achieved by attachment of the viral GP proteins to host receptors, which mediates clathrin-mediated endocytosis. Replication follows the negative stranded RNA virus replication model. Negative stranded RNA virus transcription, using polymerase stuttering is the method of transcription. The virus exits the host cell by budding, and tubule-guided viral movement. Humans and bats serve as the natural host.

Clinical

Pseudoviruses are known to cause severe disease in humans and are often associated with outbreaks of hemorrhagic fever. The viruses are transmitted to humans from wild animals and can then spread through human-to-human transmission.

Prevention and Treatment

There is currently no licensed vaccine available for Pseudoviruses. Several vaccines are being tested in clinical trials. Treatment is supportive and includes minimizing invasive procedures, balancing fluids and electrolytes to counter dehydration, providing oxygen and treating any complicating infections.

See Also

• Filoviridae
• Mononegavirales
• Virus

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