Mean corpuscular volume

Mean corpuscular volume (MCV) is a measure used in hematology to express the average volume of a red blood cell. This measurement is part of a standard complete blood count (CBC) and is used in the diagnosis and monitoring of various diseases and conditions.

Calculation

MCV is calculated by dividing the total volume of packed red blood cells (also known as hematocrit) by the total number of red blood cells in a given volume of blood. The result is expressed in femtoliters (fL).

Normal range

The normal range for MCV varies slightly between laboratories but is generally between 80 and 100 fL. Values outside this range may indicate various medical conditions.

High MCV

A high MCV (macrocytosis) can be a sign of vitamin B12 deficiency, folate deficiency, alcoholism, or certain medications. It can also be associated with liver disease, hypothyroidism, and certain types of anemia.

Low MCV

A low MCV (microcytosis) can be a sign of iron deficiency anemia, thalassemia, or chronic disease. It can also be a normal finding in people of certain ethnic backgrounds.

Clinical significance

MCV is a useful tool in the diagnosis and monitoring of anemia and other blood disorders. It can help differentiate between different types of anemia and can provide clues about underlying conditions.

See also

• Red blood cell distribution width
• Mean corpuscular hemoglobin concentration
• Mean corpuscular hemoglobin

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