Levofenfluramine

Levofenfluramine is a drug that was previously used as an appetite suppressant, but was withdrawn from the market due to its potential to cause pulmonary hypertension and heart valve disease. It is the levorotatory enantiomer of the amphetamine derivative fenfluramine.

History

Levofenfluramine was first synthesized in the 1970s and was marketed as an appetite suppressant. However, it was withdrawn from the market in the late 1990s due to concerns about its potential to cause pulmonary hypertension and heart valve disease.

Pharmacology

Levofenfluramine acts as a serotonin releasing agent. It increases the concentration of serotonin in the brain, which leads to a decrease in appetite. However, it also has the potential to cause pulmonary hypertension and heart valve disease.

Side Effects

The most common side effects of levofenfluramine include dizziness, dry mouth, insomnia, and constipation. However, the most serious side effects are pulmonary hypertension and heart valve disease.

Withdrawal from the Market

Levofenfluramine was withdrawn from the market in the late 1990s due to concerns about its potential to cause pulmonary hypertension and heart valve disease. This decision was based on several studies that showed a significant increase in the risk of these conditions in people who used the drug.

See Also

• Fenfluramine
• Appetite suppressant
• Pulmonary hypertension
• Heart valve disease

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