TRAPPC9

TRAPPC9 (also known as NIBP or NIK- and IKK-beta-binding protein) is a protein that in humans is encoded by the TRAPPC9 gene. It is involved in the regulation of cell growth and cell division, and mutations in this gene have been associated with mental retardation, autism, and obesity.

Function

TRAPPC9 is part of the TRAPP (Transport Protein Particle) complex, which is involved in protein transport within the cell. Specifically, TRAPPC9 is thought to play a role in the activation of NF-kappa B, a protein complex that controls DNA transcription, cytokine production, and cell survival.

Clinical significance

Mutations in the TRAPPC9 gene have been associated with a form of intellectual disability that is often accompanied by autism spectrum disorder and obesity. These mutations are thought to disrupt the normal function of the TRAPP complex, leading to abnormalities in cell growth and division.

Research

Research into the role of TRAPPC9 in disease is ongoing. Studies have suggested that the protein may also be involved in the development of certain types of cancer, including breast cancer and colorectal cancer.

See also

• TRAPP
• NF-kappa B
• Intellectual disability
• Autism spectrum disorder
• Obesity

References

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External links

• TRAPPC9 at the National Center for Biotechnology Information

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