IL-4

IL-4 or Interleukin 4 is a type of interleukin that is a cytokine produced by T cells in response to antigen stimulation. It has many roles in the immune system, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of B cells into plasma cells. It is a key regulator in humoral and adaptive immunity.

Function

IL-4 induces B-cell class switching to IgE, and up-regulates MHC class II production. IL-4 decreases the production of Th1 cells, macrophages, IFN-gamma, and dendritic cell IL-12. Overproduction of IL-4 is associated with allergies.

Clinical significance

IL-4 has been associated with several diseases including asthma, rheumatoid arthritis, and cancer. It is also involved in the pathogenesis of allergies and autoimmune diseases.

See also

• Interleukin
• Cytokine
• T cells
• B cells
• Plasma cell
• Humoral immunity
• Adaptive immunity
• MHC class II
• Th1 cells
• Macrophages
• IFN-gamma
• Dendritic cell
• IL-12
• Allergies
• Asthma
• Rheumatoid arthritis
• Cancer
• Autoimmune diseases

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