Estrone (medication)

Estrone is a naturally occurring estrogen steroid hormone and a minor female sex hormone. It is one of three major endogenous estrogens, the others being estradiol and estriol. Estrone, as a hormone, is used in hormone replacement therapy, usually in combination with progesterone.

Chemical Structure and Function

Estrone is an aromatic compound with a three-ring structure. It is derived from cholesterol and is converted to estradiol, a more potent form of estrogen, in the body. Estrone is primarily produced and released by the ovaries, but it can also be produced by the adrenal glands and the fat cells in both men and women.

Estrone's primary function is to prepare the uterus for implantation of a fertilized ovum. It also helps to maintain secondary female sex characteristics, such as breast development and the menstrual cycle.

Medical Uses

Estrone is used in hormone replacement therapy to treat symptoms of menopause such as hot flashes and vaginal dryness. It is also used to prevent osteoporosis in postmenopausal women. In addition, estrone can be used in the treatment of breast cancer and prostate cancer.

Side Effects and Risks

Like all medications, estrone can have side effects. These may include nausea, vomiting, bloating, stomach cramps, changes in weight or appetite, and breast tenderness. More serious side effects can include blood clots, stroke, heart attack, and cancer of the uterus.

See Also

• Estrogen
• Hormone replacement therapy
• Menopause
• Osteoporosis
• Breast cancer
• Prostate cancer

References

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