Dissolution

Dissolution is a process in which a solid substance solubilizes in a certain solvent to yield a solution. This process is widely used in the pharmaceutical industry, particularly in the development of drugs and medications.

Overview

Dissolution is a critical process in the pharmaceutical industry as it can affect the bioavailability of a drug. The rate of dissolution of a substance is determined by the Noyes-Whitney equation, which takes into account the surface area of the solid, the diffusion coefficient of the solvent, and the concentration of the solid in the solvent.

Dissolution Testing

Dissolution testing is a standard method used in the pharmaceutical industry to determine the dissolution rate of a drug. This test is important in the development of drugs as it can predict the in vivo (in the body) dissolution and absorption of the drug.

Factors Affecting Dissolution

Several factors can affect the dissolution rate of a drug. These include the particle size of the drug, the temperature of the solvent, the pH of the solvent, and the presence of surfactants.

See Also

• Solubility
• Bioavailability
• Pharmaceutical industry

References

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