CCL5

CCL5 also known as RANTES (Regulated upon Activation, Normal T cell Expressed and presumably Secreted) is a chemokine that is produced by a variety of cells including T cells, platelets, and endothelial cells. It is involved in the recruitment of leukocytes into inflammatory sites.

Function

CCL5 is a chemokine that is secreted by certain cells such as T cells and macrophages. It is involved in the immune response by attracting leukocytes towards the site of inflammation. It does this by binding to a variety of different chemokine receptors including CCR1, CCR3, CCR4 and CCR5.

Clinical significance

CCL5 has been implicated in a number of diseases, including atherosclerosis, rheumatoid arthritis, and certain types of cancer. It is also involved in the HIV infection process, as the virus uses the CCR5 receptor, which CCL5 binds to, to enter cells.

See also

• Chemokine
• Chemokine receptor
• T cell
• Macrophage
• Leukocyte
• Atherosclerosis
• Rheumatoid arthritis
• HIV

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