CAMP responsive element modulator

CAMP responsive element modulator (CREM) is a protein that in humans is encoded by the CREM gene. CREM is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome.

Function

The CREM gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway.

Clinical significance

Alterations in CREM gene function can lead to various medical conditions. For instance, mutations in this gene have been associated with major depressive disorders and autoimmune diseases.

See also

• CREB
• cAMP
• Transcription factor

References

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External links

• GeneCards

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