CALCRL

CALCRL or Calcitonin receptor-like is a protein that in humans is encoded by the CALCRL gene. It is a member of the G protein-coupled receptor superfamily. This receptor is functionally coupled to the G proteins that stimulate adenylate cyclase.

Function

The CALCRL protein is a receptor for calcitonin gene-related peptide (CGRP). Together with RAMP1, it forms the CGRP1 receptor. This receptor is involved in the transmission of pain. The RAMP1 protein can cause the CALCRL protein to switch its affinity to another peptide called Adrenomedullin.

Clinical significance

Mutations in the CALCRL gene have been associated with migraine disorders. CGRP and its receptor (CALCRL) have been identified as a key factor in migraine pathophysiology. Drugs that block CGRP or its receptor are effective for the treatment and prevention of migraines.

See also

• Calcitonin gene-related peptide receptor
• Adrenomedullin receptor
• Receptor activity-modifying protein

References

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External links

• CALCRL at GeneCards

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