ABCF2

ABCF2 is a gene that encodes a protein in humans. It is a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This gene is a member of the MDR/TAP subfamily.

Function

The protein encoded by the ABCF2 gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The function of this mitochondrial protein is unknown. However, this gene is upregulated in a number of cancer cell lines. The gene is located in the mitochondria, which are the energy-producing organelles in cells.

Clinical Significance

The ABCF2 gene has been found to be upregulated in several types of cancer, including breast cancer and prostate cancer. This suggests that it may play a role in the development or progression of these cancers. However, more research is needed to understand the exact role of ABCF2 in cancer.

See Also

• ATP-binding cassette transporter
• Mitochondria
• Cancer

References

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