TAS2R50: Difference between revisions
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'''TAS2R50''' is a [[ | |||
{{Infobox gene | |||
| name = TAS2R50 | |||
| symbol = TAS2R50 | |||
| HGNCid = 14856 | |||
| chromosome = 12 | |||
| arm = p | |||
| band = 13.2 | |||
}} | |||
'''TAS2R50''' is a member of the [[TAS2R]] family of [[taste receptors]], specifically involved in the perception of [[bitter taste]]. These receptors are [[G protein-coupled receptors]] (GPCRs) that are expressed in [[taste buds]] and are responsible for detecting bitter compounds. | |||
== Function == | == Function == | ||
TAS2R50, like other [[bitter taste receptors]], plays a crucial role in the detection of potentially harmful substances, as many bitter compounds are toxic. The activation of TAS2R50 by bitter substances triggers a signal transduction pathway that results in the perception of bitterness, which can lead to aversive behavior and avoidance of the bitter substance. | |||
== | == Genetic Variability == | ||
The TAS2R50 gene exhibits significant [[genetic variation]] among different populations, which can influence individual differences in taste perception. Variants of TAS2R50 have been associated with differences in sensitivity to certain bitter compounds, which may affect dietary preferences and nutrition. | |||
[[ | == Clinical Significance == | ||
Research has suggested that variations in the TAS2R50 gene may be linked to [[cardiovascular disease]] risk. Some studies have found associations between TAS2R50 polymorphisms and [[atherosclerosis]], although the mechanisms are not fully understood. Further research is needed to elucidate the role of TAS2R50 in cardiovascular health. | |||
== See | == See Also == | ||
* [[Taste receptor]] | * [[Taste receptor]] | ||
* [[Bitter taste receptor]] | |||
* [[G protein-coupled receptor]] | * [[G protein-coupled receptor]] | ||
== References == | == References == | ||
<references /> | <references /> | ||
[[ | == External Links == | ||
[[Category:Taste]] | * [https://www.wikimd.com/wiki/TAS2R50 TAS2R50 on WikiMD] | ||
* [https://www.ncbi.nlm.nih.gov/gene/259293 TAS2R50 Gene - NCBI] | |||
[[Category:Taste receptors]] | |||
[[Category:G protein-coupled receptors]] | [[Category:G protein-coupled receptors]] | ||
[[Category:Human genes]] | |||
Latest revision as of 20:44, 30 December 2024
| Symbol | TAS2R50 |
|---|---|
| HGNC ID | 14856 |
| Alternative symbols | – |
| Entrez Gene | – |
| OMIM | – |
| RefSeq | – |
| UniProt | – |
| Chromosome | 12p13.2 |
| Locus supplementary data | – |
TAS2R50 is a member of the TAS2R family of taste receptors, specifically involved in the perception of bitter taste. These receptors are G protein-coupled receptors (GPCRs) that are expressed in taste buds and are responsible for detecting bitter compounds.
Function[edit]
TAS2R50, like other bitter taste receptors, plays a crucial role in the detection of potentially harmful substances, as many bitter compounds are toxic. The activation of TAS2R50 by bitter substances triggers a signal transduction pathway that results in the perception of bitterness, which can lead to aversive behavior and avoidance of the bitter substance.
Genetic Variability[edit]
The TAS2R50 gene exhibits significant genetic variation among different populations, which can influence individual differences in taste perception. Variants of TAS2R50 have been associated with differences in sensitivity to certain bitter compounds, which may affect dietary preferences and nutrition.
Clinical Significance[edit]
Research has suggested that variations in the TAS2R50 gene may be linked to cardiovascular disease risk. Some studies have found associations between TAS2R50 polymorphisms and atherosclerosis, although the mechanisms are not fully understood. Further research is needed to elucidate the role of TAS2R50 in cardiovascular health.
See Also[edit]
References[edit]
<references />
