LPAR6: Difference between revisions
CSV import |
CSV import |
||
| Line 1: | Line 1: | ||
'''LPAR6''' | |||
{{Infobox gene | |||
| name = LPAR6 | |||
| symbol = LPAR6 | |||
| HGNCid = 18610 | |||
| chromosome = 13 | |||
| arm = q | |||
| band = 14 | |||
}} | |||
'''LPAR6''' (Lysophosphatidic acid receptor 6) is a [[G protein-coupled receptor]] (GPCR) that is encoded by the '''LPAR6''' gene in humans. This receptor is part of the [[lysophospholipid receptor]] family, which is involved in various cellular processes, including [[cell proliferation]], [[migration]], and [[survival]]. | |||
== Function == | == Function == | ||
LPAR6 is | LPAR6 is primarily activated by [[lysophosphatidic acid]] (LPA), a bioactive lipid that mediates diverse biological functions. The receptor is known to play a crucial role in the regulation of [[hair growth]] and [[skin homeostasis]]. Mutations in the LPAR6 gene have been associated with [[hypotrichosis]] and other hair growth disorders. | ||
== Clinical Significance == | |||
Mutations in the LPAR6 gene can lead to [[autosomal recessive hypotrichosis]], a condition characterized by sparse hair growth on the scalp and body. This condition is part of a group of disorders known as [[ectodermal dysplasias]], which affect the development of the skin, hair, nails, and teeth. | |||
== | == Pathways == | ||
LPAR6 is involved in several signaling pathways, including the [[RhoA]] and [[Ras]] pathways, which are important for cytoskeletal organization and cell motility. The receptor's activation can lead to the phosphorylation of downstream targets, influencing various cellular responses. | |||
== Research == | |||
Ongoing research is focused on understanding the precise mechanisms by which LPAR6 influences hair growth and its potential role in other physiological and pathological processes. Studies are also exploring the therapeutic potential of targeting LPAR6 in conditions such as [[alopecia]] and [[cancer]]. | |||
== See also == | == See also == | ||
* [[ | * [[G protein-coupled receptor]] | ||
* [[Lysophosphatidic acid]] | |||
* [[Hypotrichosis]] | * [[Hypotrichosis]] | ||
== References == | == References == | ||
<references /> | <references/> | ||
== External links == | == External links == | ||
* [ | * [https://www.ncbi.nlm.nih.gov/gene/10161 LPAR6 gene - NCBI] | ||
* [https://www.genecards.org/cgi-bin/carddisp.pl?gene=LPAR6 LPAR6 - GeneCards] | |||
[[Category:Genes on human chromosome 13]] | |||
[[Category:G protein-coupled receptors]] | [[Category:G protein-coupled receptors]] | ||
[[Category:Human proteins]] | [[Category:Human proteins]] | ||
[[Category: | [[Category:Receptors]] | ||
Latest revision as of 20:30, 30 December 2024
| Symbol | LPAR6 |
|---|---|
| HGNC ID | 18610 |
| Alternative symbols | – |
| Entrez Gene | – |
| OMIM | – |
| RefSeq | – |
| UniProt | – |
| Chromosome | 13q14 |
| Locus supplementary data | – |
LPAR6 (Lysophosphatidic acid receptor 6) is a G protein-coupled receptor (GPCR) that is encoded by the LPAR6 gene in humans. This receptor is part of the lysophospholipid receptor family, which is involved in various cellular processes, including cell proliferation, migration, and survival.
Function[edit]
LPAR6 is primarily activated by lysophosphatidic acid (LPA), a bioactive lipid that mediates diverse biological functions. The receptor is known to play a crucial role in the regulation of hair growth and skin homeostasis. Mutations in the LPAR6 gene have been associated with hypotrichosis and other hair growth disorders.
Clinical Significance[edit]
Mutations in the LPAR6 gene can lead to autosomal recessive hypotrichosis, a condition characterized by sparse hair growth on the scalp and body. This condition is part of a group of disorders known as ectodermal dysplasias, which affect the development of the skin, hair, nails, and teeth.
Pathways[edit]
LPAR6 is involved in several signaling pathways, including the RhoA and Ras pathways, which are important for cytoskeletal organization and cell motility. The receptor's activation can lead to the phosphorylation of downstream targets, influencing various cellular responses.
Research[edit]
Ongoing research is focused on understanding the precise mechanisms by which LPAR6 influences hair growth and its potential role in other physiological and pathological processes. Studies are also exploring the therapeutic potential of targeting LPAR6 in conditions such as alopecia and cancer.
See also[edit]
References[edit]
<references/>
