ERMAP: Difference between revisions

Latest revision as of 17:32, 30 December 2024

ERMAP (Erythroblast Membrane-Associated Protein) is a protein that in humans is encoded by the ERMAP gene. This protein is associated with the Scianna blood group system.

Function[edit]

ERMAP is a cell adhesion molecule that is expressed in erythroblasts and mature red blood cells. It plays a role in the adhesion of erythroid cells to the extracellular matrix and may be involved in the maturation of erythrocytes.

Clinical significance[edit]

Mutations in the ERMAP gene can lead to Scianna blood group system variations, which can be significant in blood transfusion and transplantation. The Scianna blood group system is one of the blood group systems recognized by the International Society of Blood Transfusion.

Structure[edit]

The ERMAP protein is a member of the immunoglobulin superfamily and contains immunoglobulin-like domains. It is a transmembrane protein with a single transmembrane helix.

References[edit]

External links[edit]

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-'''ERMAP''' (Erythroblast Membrane-Associated Protein) is a [[protein]] that in humans is encoded by the ERMAP [[gene]]. This protein is a cell surface transmembrane protein that is predominantly expressed in developing [[erythrocytes]] and [[endothelial cells]]. It has been implicated in the adhesion of erythroblasts to [[bone marrow]] stromal cells, a critical step in erythropoiesis, the process of producing red blood cells.
-== Function ==
+{{Infobox protein
+| name = ERMAP
+| image = <!-- Image removed -->
+| caption =
+| symbol = ERMAP
+| alt_symbols =
+| EntrezGene = 114625
+| HGNCid = 18126
+| OMIM = 606951
+| RefSeq = NM_018687
+| UniProt = Q96NL4
+| chromosome = 1
+| arm = p
+| band = 34
+}}
-ERMAP is a member of the [[SCAM family]] of proteins, which are characterized by the presence of a scavenger receptor cysteine-rich (SRCR) domain. The SRCR domain is a protein module that is found in a wide variety of proteins involved in the immune response. In the case of ERMAP, the SRCR domain is thought to mediate the protein's role in cell adhesion.
+'''ERMAP''' (Erythroblast Membrane-Associated Protein) is a [[protein]] that in humans is encoded by the '''ERMAP''' [[gene]]. This protein is associated with the [[Scianna blood group system]].
-In addition to its role in erythropoiesis, ERMAP has also been implicated in the regulation of [[angiogenesis]], the process of new blood vessel formation. This is due to its expression in endothelial cells, which line the interior surface of blood vessels and lymphatic vessels.
+== Function ==
+ERMAP is a [[cell adhesion molecule]] that is expressed in [[erythroblasts]] and [[mature red blood cells]]. It plays a role in the [[adhesion]] of [[erythroid cells]] to the [[extracellular matrix]] and may be involved in the [[maturation]] of [[erythrocytes]].
 == Clinical significance ==
+Mutations in the ERMAP gene can lead to [[Scianna blood group system]] variations, which can be significant in [[blood transfusion]] and [[transplantation]]. The Scianna blood group system is one of the [[blood group systems]] recognized by the [[International Society of Blood Transfusion]].
-Mutations in the ERMAP gene have been associated with [[blood disorders]] such as [[anemia]] and [[thalassemia]]. These disorders are characterized by a reduced ability to produce red blood cells, which can lead to symptoms such as fatigue, weakness, and shortness of breath.
+== Structure ==
+The ERMAP protein is a member of the [[immunoglobulin superfamily]] and contains [[immunoglobulin-like domains]]. It is a [[transmembrane protein]] with a single [[transmembrane helix]].
-== Research ==
-Research into ERMAP is ongoing, with scientists seeking to better understand its role in erythropoiesis and angiogenesis, as well as its potential as a therapeutic target for blood disorders.
-[[File:ERMAP protein structure.jpg|thumb|right|300px|The structure of the ERMAP protein. Image from Wikimedia Commons.]]
 == See also ==
+* [[Blood group systems]]
-* [[Erythropoiesis]]
+* [[Erythrocyte]]
-* [[Angiogenesis]]
+* [[Cell adhesion]]
-* [[Blood disorders]]
-* [[Anemia]]
-* [[Thalassemia]]
 == References ==
+{{Reflist}}
-<references />
+== External links ==
+* {{GeneReviews|Scianna}}
-[[Category:Proteins]]
+* {{OMIM|606951}}
-[[Category:Genes]]
-[[Category:Blood]]
-[[Category:Medicine]]
-{{Protein-stub}}
+[[Category:Blood proteins]]
-{{Medicine-stub}}
+[[Category:Blood antigen systems]]
+[[Category:Transmembrane proteins]]
+[[Category:Immunoglobulin superfamily]]