Tenascin X: Difference between revisions

Latest revision as of 21:47, 29 December 2024

Tenascin-X is a large extracellular matrix glycoprotein that plays a crucial role in the structural integrity of connective tissues. It is encoded by the TNXB gene located on chromosome 6 in humans.

Function[edit]

Tenascin-X is involved in the organization and maintenance of the extracellular matrix, which provides structural support to tissues and influences cell behavior. It is particularly important in the skin, muscles, and blood vessels.

Clinical significance[edit]

Mutations in the TNXB gene can lead to a condition known as Ehlers-Danlos syndrome type tenascin-X deficient, which is characterized by hyperelastic skin, joint hypermobility, and tissue fragility. This condition highlights the importance of tenascin-X in maintaining tissue integrity.

Interactions[edit]

Tenascin-X interacts with other extracellular matrix proteins and cell surface receptors, influencing cell adhesion, migration, and proliferation. These interactions are critical for tissue repair and development.

References[edit]

External links[edit]

   This article is a protein-related stub. You can help WikiMD by expanding it!

Template:Ehlers-Danlos syndrome

@@ Line 1: / Line 1: @@
-'''Tenascin X''' is a [[protein]] that in humans is encoded by the ''TNXB'' [[gene]]. It is a member of the [[tenascin]] family, which are extracellular matrix proteins expressed at high levels during [[embryogenesis]] and in certain pathological conditions.
+{{Infobox protein
+| name = Tenascin-X
+| image = <!-- Image removed -->
+| caption = <!-- Caption removed -->
+| symbol = TNXB
+| gene = TNXB
+| chromosome = 6
+| arm = p
+| band = 21.3
+}}
+'''Tenascin-X''' is a large [[extracellular matrix]] [[glycoprotein]] that plays a crucial role in the [[structural integrity]] of [[connective tissues]]. It is encoded by the [[TNXB gene]] located on [[chromosome 6]] in humans.
 == Function ==
-Tenascin X is a large extracellular matrix protein that is thought to be involved in [[cell adhesion]]. It is expressed in a variety of tissues, including [[skin]], [[joints]], and [[blood vessels]]. Mutations in the ''TNXB'' gene can lead to a deficiency of Tenascin X, which is associated with certain [[connective tissue disorders]], such as [[Ehlers-Danlos syndrome]].
+Tenascin-X is involved in the organization and maintenance of the [[extracellular matrix]], which provides structural support to [[tissues]] and influences [[cell behavior]]. It is particularly important in the [[skin]], [[muscles]], and [[blood vessels]].
-== Structure ==
-The Tenascin X protein is composed of multiple domains, including [[EGF-like repeats]], [[fibronectin type III domains]], and a [[fibrinogen]]-like domain. These domains are thought to mediate the protein's interactions with other extracellular matrix components and cells.
 == Clinical significance ==
-Deficiency of Tenascin X is associated with a form of Ehlers-Danlos syndrome characterized by [[joint hypermobility]], skin hyperextensibility, and tissue fragility. This condition is caused by mutations in the ''TNXB'' gene that result in a nonfunctional Tenascin X protein.
+Mutations in the TNXB gene can lead to a condition known as [[Ehlers-Danlos syndrome]] type tenascin-X deficient, which is characterized by [[hyperelastic skin]], [[joint hypermobility]], and [[tissue fragility]]. This condition highlights the importance of tenascin-X in maintaining [[tissue integrity]].
-[[File:Tenascin X.png|thumb|right|Structure of Tenascin X protein]]
-== Research ==
+== Interactions ==
-Research into Tenascin X is ongoing, with studies focusing on its role in tissue structure and function, as well as its potential involvement in other diseases, such as [[fibromyalgia]] and certain types of [[cancer]].
+Tenascin-X interacts with other [[extracellular matrix proteins]] and [[cell surface receptors]], influencing [[cell adhesion]], [[migration]], and [[proliferation]]. These interactions are critical for [[tissue repair]] and [[development]].
 == See also ==
-* [[Tenascin]]
+* [[Extracellular matrix]]
+* [[Connective tissue]]
 * [[Ehlers-Danlos syndrome]]
-* [[Extracellular matrix]]
-* [[Protein structure]]
 == References ==
 <references />
-[[Category:Proteins]]
+== External links ==
-[[Category:Genes]]
+* [https://www.ncbi.nlm.nih.gov/gene/7148 TNXB gene - NCBI]
-[[Category:Medical genetics]]
+* [https://ghr.nlm.nih.gov/gene/TNXB TNXB - Genetics Home Reference]
-[[Category:Connective tissue diseases]]
-{{medicine-stub}}
+{{Protein-stub}}
+{{Ehlers-Danlos syndrome}}
+[[Category:Extracellular matrix proteins]]
+[[Category:Genes on human chromosome 6]]
+[[Category:Glycoproteins]]