Bert W. O'Malley: Difference between revisions

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[[File:O'malley.jpg|thumb]] [[File:O'malley.jpg|thumb]] {{Infobox scientist
{{Infobox scientist
| name = Bert W. O'Malley
| name = Bert W. O'Malley
| image = <!-- No image available -->
| image = <!-- Image removed -->
| birth_date = <!-- Birth date -->
| image_size = <!-- Image size removed -->
| birth_place = <!-- Birth place -->
| alt = <!-- Alt text removed -->
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| birth_place = <!-- Birth place removed -->
| death_date = <!-- Death date removed -->
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| nationality = American
| nationality = American
| fields = Molecular Biology, Endocrinology
| fields = [[Endocrinology]], [[Molecular Biology]]
| workplaces = Baylor College of Medicine
| workplaces = [[Baylor College of Medicine]]
| alma_mater = University of Pittsburgh
| alma_mater = [[University of Pittsburgh]]
| known_for = Steroid Receptor Coactivators
| doctoral_advisor = <!-- Doctoral advisor removed -->
| awards = National Medal of Science, Lasker Award
| known_for = [[Steroid Receptor Coactivators]]
| awards = [[National Medal of Science]]
}}
}}


'''Bert W. O'Malley''' is a prominent American [[molecular biologist]] and [[endocrinologist]] known for his pioneering work in the field of [[steroid receptor coactivators]]. His research has significantly advanced the understanding of [[hormone action]] and [[gene regulation]].
'''Bert W. O'Malley''' is a prominent American [[endocrinologist]] and [[molecular biologist]] known for his pioneering research in the field of [[steroid receptor coactivators]]. He is currently a professor at [[Baylor College of Medicine]].


== Early Life and Education ==
== Early Life and Education ==
Bert W. O'Malley was born in [[Pittsburgh, Pennsylvania]]. He pursued his undergraduate studies at the [[University of Pittsburgh]], where he developed an interest in [[biochemistry]] and [[molecular biology]]. O'Malley continued his education at the same institution, earning his [[Doctor of Medicine|M.D.]] degree.
Bert W. O'Malley was born in [[Pittsburgh, Pennsylvania]]. He completed his undergraduate studies at the [[University of Pittsburgh]], where he developed an interest in [[biochemistry]] and [[molecular biology]].


== Career and Research ==
== Career ==
O'Malley's career began with a focus on the mechanisms of [[hormone action]] at the molecular level. He joined the [[Baylor College of Medicine]] where he established a laboratory dedicated to the study of [[steroid hormones]] and their receptors.
O'Malley began his career at [[Vanderbilt University]] before moving to [[Baylor College of Medicine]], where he has made significant contributions to the understanding of [[hormone action]] and [[gene regulation]]. His work has focused on the role of [[nuclear receptors]] and their coactivators in [[gene expression]].


=== Steroid Receptor Coactivators ===
== Research ==
One of O'Malley's most significant contributions is the discovery and characterization of [[steroid receptor coactivators]] (SRCs). These coactivators are proteins that interact with [[nuclear receptors]] to enhance the transcription of specific genes. O'Malley's work demonstrated that SRCs are crucial for the full transcriptional activity of steroid hormone receptors, such as the [[estrogen receptor]] and [[androgen receptor]].
O'Malley's research has been instrumental in elucidating the mechanisms by which [[steroid hormones]] regulate [[gene transcription]]. He discovered the family of [[steroid receptor coactivators]] (SRCs), which are essential for the [[transcriptional activity]] of [[nuclear receptors]]. This discovery has had a profound impact on the field of [[endocrinology]] and has implications for the treatment of [[hormone-related diseases]].
 
=== Impact on Medicine ===
O'Malley's research has had profound implications for the treatment of [[hormone-dependent cancers]], such as [[breast cancer]] and [[prostate cancer]]. By understanding the role of coactivators in hormone signaling, new therapeutic targets have been identified, leading to the development of drugs that can modulate these pathways.


== Awards and Honors ==
== Awards and Honors ==
Bert W. O'Malley has received numerous awards for his contributions to science, including the [[National Medal of Science]] and the [[Albert Lasker Award for Basic Medical Research]]. His work has been recognized for its impact on both basic science and clinical applications.
Bert W. O'Malley has received numerous awards for his contributions to science, including the prestigious [[National Medal of Science]]. He is a member of the [[National Academy of Sciences]] and has been recognized by various scientific organizations for his groundbreaking research.


== Also see ==
== See Also ==
* [[Steroid hormone receptor]]
* [[Gene transcription]]
* [[Nuclear receptor]]
* [[Endocrinology]]
* [[Endocrinology]]
* [[Molecular biology]]
* [[Molecular Biology]]
* [[Steroid Hormones]]
* [[Gene Regulation]]
 
== References ==
{{Reflist}}


{{Authority control}}
== External Links ==
* [Baylor College of Medicine Faculty Page](https://www.bcm.edu/)


[[Category:American biologists]]
{{DEFAULTSORT:O'Malley, Bert W.}}
[[Category:Endocrinologists]]
[[Category:American endocrinologists]]
[[Category:Living people]]
[[Category:American molecular biologists]]
[[Category:University of Pittsburgh alumni]]
[[Category:University of Pittsburgh alumni]]
[[Category:Baylor College of Medicine faculty]]
[[Category:Baylor College of Medicine faculty]]
[[Category:National Medal of Science laureates]]
[[Category:Living people]]

Latest revision as of 21:20, 27 December 2024

Bert W. O'Malley







NationalityAmerican
Known forSteroid Receptor Coactivators
AwardsNational Medal of Science


Bert W. O'Malley is a prominent American endocrinologist and molecular biologist known for his pioneering research in the field of steroid receptor coactivators. He is currently a professor at Baylor College of Medicine.

Early Life and Education[edit]

Bert W. O'Malley was born in Pittsburgh, Pennsylvania. He completed his undergraduate studies at the University of Pittsburgh, where he developed an interest in biochemistry and molecular biology.

Career[edit]

O'Malley began his career at Vanderbilt University before moving to Baylor College of Medicine, where he has made significant contributions to the understanding of hormone action and gene regulation. His work has focused on the role of nuclear receptors and their coactivators in gene expression.

Research[edit]

O'Malley's research has been instrumental in elucidating the mechanisms by which steroid hormones regulate gene transcription. He discovered the family of steroid receptor coactivators (SRCs), which are essential for the transcriptional activity of nuclear receptors. This discovery has had a profound impact on the field of endocrinology and has implications for the treatment of hormone-related diseases.

Awards and Honors[edit]

Bert W. O'Malley has received numerous awards for his contributions to science, including the prestigious National Medal of Science. He is a member of the National Academy of Sciences and has been recognized by various scientific organizations for his groundbreaking research.

See Also[edit]

References[edit]

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External Links[edit]