ADAM7: Difference between revisions

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<br>= ADAM7 =
ADAM7


ADAM7, also known as A Disintegrin and Metalloproteinase domain-containing protein 7, is a member of the ADAM family of proteins. These proteins are characterized by their role in cell signaling, adhesion, and proteolysis. ADAM7 is encoded by the ''ADAM7'' gene in humans.
ADAM7 is a member of the ADAM (A Disintegrin and Metalloproteinase) family of proteins, which are involved in a variety of biological processes, including cell signaling, adhesion, and migration. These proteins are characterized by their complex structure, which includes a disintegrin domain and a metalloproteinase domain, among others.


== Structure ==
==Structure==
ADAM7 is a type I transmembrane protein that consists of several distinct domains:
ADAM7, like other members of the ADAM family, is a type I transmembrane protein. It consists of several distinct domains:


* '''Signal Peptide''': Directs the nascent protein to the secretory pathway.
* '''[[Pro-domain]]''': This domain is involved in the regulation of the protein's activity. It is typically cleaved off to activate the protein.
* '''Pro-domain''': Maintains the enzyme in an inactive form until it is cleaved.
* '''[[Metalloproteinase domain]]''': This domain has enzymatic activity and is responsible for the proteolytic functions of the protein.
* '''Metalloprotease Domain''': Although ADAM7 contains this domain, it is catalytically inactive due to the absence of a critical zinc-binding motif.
* '''[[Disintegrin domain]]''': This domain is involved in cell adhesion processes.
* '''Disintegrin Domain''': Involved in cell adhesion processes.
* '''[[Cysteine-rich domain]]''': This domain may play a role in protein-protein interactions.
* '''Cysteine-rich Domain''': May play a role in protein-protein interactions.
* '''[[EGF-like domain]]''': This domain is similar to epidermal growth factor and may be involved in cell signaling.
* '''EGF-like Domain''': Potentially involved in cell signaling.
* '''[[Transmembrane domain]]''': This domain anchors the protein in the cell membrane.
* '''Transmembrane Domain''': Anchors the protein in the cell membrane.
* '''[[Cytoplasmic tail]]''': This domain may be involved in intracellular signaling pathways.
* '''Cytoplasmic Tail''': May interact with intracellular signaling molecules.


== Function ==
==Function==
ADAM7 is primarily expressed in the epididymis and is thought to play a role in sperm maturation and male fertility. Unlike other ADAM proteins, ADAM7 lacks proteolytic activity, suggesting its function is more related to cell adhesion and signaling rather than proteolysis.
ADAM7 is primarily expressed in the testis and is thought to play a role in sperm maturation and fertilization. Unlike some other ADAM proteins, ADAM7 lacks proteolytic activity due to the absence of a critical zinc-binding motif in its metalloproteinase domain. Instead, it is believed to function in cell adhesion and signaling.


== Expression ==
==Clinical Significance==
The expression of ADAM7 is highly tissue-specific, with significant levels found in the epididymis, pancreas, and certain cancerous tissues. Its expression is regulated by hormonal and developmental cues.
While the precise physiological role of ADAM7 is not fully understood, alterations in its expression have been associated with certain diseases. For example, changes in ADAM7 expression levels have been observed in some cancers, suggesting a potential role in tumor progression or metastasis.


== Clinical Significance ==
==Research==
ADAM7 has been implicated in various pathological conditions, including cancer. Its expression is altered in pancreatic cancer, and it may serve as a potential biomarker for the disease. Additionally, ADAM7 has been studied in the context of male infertility, given its role in sperm maturation.
Ongoing research is focused on elucidating the specific functions of ADAM7 in reproductive biology and its potential implications in cancer biology. Understanding the role of ADAM7 could lead to new insights into cell adhesion mechanisms and the development of novel therapeutic strategies.


== Research ==
==Also see==
Ongoing research is focused on understanding the precise biological functions of ADAM7, its role in disease, and its potential as a therapeutic target. Studies are exploring its interactions with other proteins and its involvement in signaling pathways.
* [[ADAM family]]
* [[Metalloproteinase]]
* [[Cell adhesion]]
* [[Sperm maturation]]
* [[Cancer biology]]


== References ==
{{ADAM family}}
* Blobel, C. P. (2005). ADAMs: key components in EGFR signalling and development. ''Nature Reviews Molecular Cell Biology'', 6(1), 32-43.
* Edwards, D. R., & Handsley, M. M. (2008). ADAM metalloproteinases: biological roles and potential as therapeutic targets. ''Expert Opinion on Therapeutic Targets'', 12(11), 1347-1357.
* Hsia, H. E., & Blobel, C. P. (2012). The ADAM family: coordinators of nervous system development, plasticity and repair. ''Nature Reviews Neuroscience'', 13(12), 759-771.
 
== External Links ==
* [GeneCards: ADAM7](https://www.genecards.org/cgi-bin/carddisp.pl?gene=ADAM7)
* [UniProt: ADAM7](https://www.uniprot.org/uniprot/Q9H2U9)


[[Category:Proteins]]
[[Category:Proteins]]
[[Category:Human genes]]
[[Category:Enzymes]]
[[Category:Cell signaling]]
[[Category:Cell biology]]
[[Category:Reproductive biology]]

Latest revision as of 22:23, 15 December 2024

ADAM7

ADAM7 is a member of the ADAM (A Disintegrin and Metalloproteinase) family of proteins, which are involved in a variety of biological processes, including cell signaling, adhesion, and migration. These proteins are characterized by their complex structure, which includes a disintegrin domain and a metalloproteinase domain, among others.

Structure[edit]

ADAM7, like other members of the ADAM family, is a type I transmembrane protein. It consists of several distinct domains:

  • Pro-domain: This domain is involved in the regulation of the protein's activity. It is typically cleaved off to activate the protein.
  • Metalloproteinase domain: This domain has enzymatic activity and is responsible for the proteolytic functions of the protein.
  • Disintegrin domain: This domain is involved in cell adhesion processes.
  • Cysteine-rich domain: This domain may play a role in protein-protein interactions.
  • EGF-like domain: This domain is similar to epidermal growth factor and may be involved in cell signaling.
  • Transmembrane domain: This domain anchors the protein in the cell membrane.
  • Cytoplasmic tail: This domain may be involved in intracellular signaling pathways.

Function[edit]

ADAM7 is primarily expressed in the testis and is thought to play a role in sperm maturation and fertilization. Unlike some other ADAM proteins, ADAM7 lacks proteolytic activity due to the absence of a critical zinc-binding motif in its metalloproteinase domain. Instead, it is believed to function in cell adhesion and signaling.

Clinical Significance[edit]

While the precise physiological role of ADAM7 is not fully understood, alterations in its expression have been associated with certain diseases. For example, changes in ADAM7 expression levels have been observed in some cancers, suggesting a potential role in tumor progression or metastasis.

Research[edit]

Ongoing research is focused on elucidating the specific functions of ADAM7 in reproductive biology and its potential implications in cancer biology. Understanding the role of ADAM7 could lead to new insights into cell adhesion mechanisms and the development of novel therapeutic strategies.

Also see[edit]


ADAM Family

A Disintegrin and Metalloproteinase

Members
Functions
Related Topics
See Also
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