60S ribosomal protein L10a

60S ribosomal protein L10a is a protein that in humans is encoded by the RPL10A gene. This protein is a component of the ribosome, specifically associating with the 60S subunit, one of the two subunits that make up a functional ribosome. The 60S subunit is the larger of the two and is responsible for the peptidyl transferase activity that forms peptide bonds between amino acids during the process of protein synthesis. The RPL10A gene is located on the chromosome 6 in humans.

Function

The 60S ribosomal protein L10a plays a critical role in the assembly and function of the 60S ribosomal subunit. It is involved in the binding of tRNA and mRNA molecules and plays a part in the catalytic steps of protein synthesis. This protein, like other ribosomal proteins, is essential for the accurate and efficient production of proteins within the cell, a process fundamental to all cellular functions and life itself.

Gene

The RPL10A gene provides instructions for making the 60S ribosomal protein L10a. Mutations in this gene can affect protein synthesis, potentially leading to various cellular dysfunctions and diseases. The study of this gene and its protein product is important for understanding the molecular mechanisms of protein synthesis and its regulation.

Clinical Significance

Alterations in the RPL10A gene have been studied in the context of their potential link to diseases. While direct associations are still under investigation, disruptions in ribosomal function, in general, have been implicated in a range of health conditions, including cancer and developmental disorders. Understanding the role of 60S ribosomal protein L10a in these conditions could lead to new insights into disease mechanisms and potential therapeutic targets.

See Also

• Ribosome
• Protein synthesis
• Ribosomal proteins

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