Uricosuric

Uricosuric is a term that refers to a class of drugs that increase the excretion of uric acid in the urine, thus reducing the concentration of uric acid in the blood. They are used to treat gout, a condition characterized by high levels of uric acid in the blood and the formation of uric acid crystals in the joints and other tissues.

Mechanism of Action

Uricosuric drugs work by inhibiting the reabsorption of uric acid in the proximal tubule of the kidney. This increases the amount of uric acid that is excreted in the urine, thereby reducing the concentration of uric acid in the blood.

Examples of Uricosuric Drugs

Some examples of uricosuric drugs include probenecid, sulfinpyrazone, and benzbromarone. These drugs are typically used in patients with chronic gout who have not responded to other treatments.

Side Effects

Like all drugs, uricosuric drugs can have side effects. These can include gastrointestinal upset, rash, and kidney stones. It is important for patients to discuss these potential side effects with their healthcare provider before starting treatment.

See Also

• Gout
• Uric Acid
• Probenecid
• Sulfinpyrazone
• Benzbromarone

References

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