Striate keratoderma: Difference between revisions
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{{Infobox medical condition | |||
| name = Striate keratoderma | |||
| synonyms = [[Linear palmoplantar keratoderma]], [[Brunauer-Fuhs-Siemens syndrome]] | |||
| specialty = [[Dermatology]] | |||
| symptoms = Thickening of the skin on the palms and soles, linear hyperkeratosis | |||
| onset = Childhood or adolescence | |||
| duration = Lifelong | |||
| causes = Genetic mutations, often in the [[KRT1]], [[KRT9]], or [[KRT16]] genes | |||
| risks = Family history of the condition | |||
| diagnosis = Clinical examination, genetic testing | |||
| differential = [[Diffuse palmoplantar keratoderma]], [[Focal palmoplantar keratoderma]] | |||
| treatment = Emollients, keratolytics, retinoids | |||
| prognosis = Generally good, but can affect quality of life | |||
| frequency = Rare | |||
}} | |||
'''Striate keratoderma''' is a rare, autosomal dominant skin disorder that is characterized by the presence of hyperkeratosis on the palms and soles. The condition is also known as [[Focal palmoplantar keratoderma]] with oral mucosal hyperkeratosis. | '''Striate keratoderma''' is a rare, autosomal dominant skin disorder that is characterized by the presence of hyperkeratosis on the palms and soles. The condition is also known as [[Focal palmoplantar keratoderma]] with oral mucosal hyperkeratosis. | ||
== Symptoms and Signs == | == Symptoms and Signs == | ||
The primary symptom of striate keratoderma is the presence of thickened skin on the palms and soles. This can lead to discomfort and pain, particularly when walking or using the hands. Other symptoms can include: | The primary symptom of striate keratoderma is the presence of thickened skin on the palms and soles. This can lead to discomfort and pain, particularly when walking or using the hands. Other symptoms can include: | ||
* [[Hyperkeratosis]]: This is a condition where the skin becomes thicker than normal. In the case of striate keratoderma, this typically occurs on the palms and soles. | * [[Hyperkeratosis]]: This is a condition where the skin becomes thicker than normal. In the case of striate keratoderma, this typically occurs on the palms and soles. | ||
* [[Palmoplantar keratoderma]]: This is a condition where the skin on the palms and soles becomes thick and rough. | * [[Palmoplantar keratoderma]]: This is a condition where the skin on the palms and soles becomes thick and rough. | ||
* [[Oral mucosal hyperkeratosis]]: This is a condition where the lining of the mouth becomes thick and rough. | * [[Oral mucosal hyperkeratosis]]: This is a condition where the lining of the mouth becomes thick and rough. | ||
== Causes == | == Causes == | ||
Striate keratoderma is caused by mutations in the [[DSG1]] gene. This gene provides instructions for making a protein that is essential for the structure and function of the skin. Mutations in the DSG1 gene disrupt the normal development of the skin, leading to the symptoms of striate keratoderma. | Striate keratoderma is caused by mutations in the [[DSG1]] gene. This gene provides instructions for making a protein that is essential for the structure and function of the skin. Mutations in the DSG1 gene disrupt the normal development of the skin, leading to the symptoms of striate keratoderma. | ||
== Diagnosis == | == Diagnosis == | ||
The diagnosis of striate keratoderma is typically made based on the presence of characteristic symptoms. A skin biopsy may be performed to confirm the diagnosis. Genetic testing may also be performed to identify mutations in the DSG1 gene. | The diagnosis of striate keratoderma is typically made based on the presence of characteristic symptoms. A skin biopsy may be performed to confirm the diagnosis. Genetic testing may also be performed to identify mutations in the DSG1 gene. | ||
== Treatment == | == Treatment == | ||
There is currently no cure for striate keratoderma. Treatment is aimed at managing the symptoms and can include the use of emollients and keratolytics to soften and reduce the thickness of the skin. In severe cases, oral retinoids may be used. | There is currently no cure for striate keratoderma. Treatment is aimed at managing the symptoms and can include the use of emollients and keratolytics to soften and reduce the thickness of the skin. In severe cases, oral retinoids may be used. | ||
== See also == | == See also == | ||
* [[Palmoplantar keratoderma]] | * [[Palmoplantar keratoderma]] | ||
* [[Hyperkeratosis]] | * [[Hyperkeratosis]] | ||
* [[DSG1]] | * [[DSG1]] | ||
[[Category:Dermatology]] | [[Category:Dermatology]] | ||
[[Category:Genetic disorders]] | [[Category:Genetic disorders]] | ||
[[Category:Skin conditions]] | [[Category:Skin conditions]] | ||
{{stub}} | {{stub}} | ||
{{dictionary-stub1}} | {{dictionary-stub1}} | ||
{{No image}} | {{No image}} | ||
Latest revision as of 03:20, 4 April 2025
| Striate keratoderma | |
|---|---|
| Synonyms | Linear palmoplantar keratoderma, Brunauer-Fuhs-Siemens syndrome |
| Pronounce | N/A |
| Specialty | Dermatology |
| Symptoms | Thickening of the skin on the palms and soles, linear hyperkeratosis |
| Complications | N/A |
| Onset | Childhood or adolescence |
| Duration | Lifelong |
| Types | N/A |
| Causes | Genetic mutations, often in the KRT1, KRT9, or KRT16 genes |
| Risks | Family history of the condition |
| Diagnosis | Clinical examination, genetic testing |
| Differential diagnosis | Diffuse palmoplantar keratoderma, Focal palmoplantar keratoderma |
| Prevention | N/A |
| Treatment | Emollients, keratolytics, retinoids |
| Medication | N/A |
| Prognosis | Generally good, but can affect quality of life |
| Frequency | Rare |
| Deaths | N/A |
Striate keratoderma is a rare, autosomal dominant skin disorder that is characterized by the presence of hyperkeratosis on the palms and soles. The condition is also known as Focal palmoplantar keratoderma with oral mucosal hyperkeratosis.
Symptoms and Signs[edit]
The primary symptom of striate keratoderma is the presence of thickened skin on the palms and soles. This can lead to discomfort and pain, particularly when walking or using the hands. Other symptoms can include:
- Hyperkeratosis: This is a condition where the skin becomes thicker than normal. In the case of striate keratoderma, this typically occurs on the palms and soles.
- Palmoplantar keratoderma: This is a condition where the skin on the palms and soles becomes thick and rough.
- Oral mucosal hyperkeratosis: This is a condition where the lining of the mouth becomes thick and rough.
Causes[edit]
Striate keratoderma is caused by mutations in the DSG1 gene. This gene provides instructions for making a protein that is essential for the structure and function of the skin. Mutations in the DSG1 gene disrupt the normal development of the skin, leading to the symptoms of striate keratoderma.
Diagnosis[edit]
The diagnosis of striate keratoderma is typically made based on the presence of characteristic symptoms. A skin biopsy may be performed to confirm the diagnosis. Genetic testing may also be performed to identify mutations in the DSG1 gene.
Treatment[edit]
There is currently no cure for striate keratoderma. Treatment is aimed at managing the symptoms and can include the use of emollients and keratolytics to soften and reduce the thickness of the skin. In severe cases, oral retinoids may be used.
