Collagen-induced arthritis

Collagen-induced arthritis
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Collagen-induced arthritis (CIA) is a condition induced in mice (or rats) to study rheumatoid arthritis.<ref name=Williams2004>,

 Collagen-induced arthritis as a model for rheumatoid arthritis, 
  
  
 2004, 
  
 Volume: 98, 
 ISBN 978-1-59259-771-0, 
 DOI: 10.1385/1-59259-771-8:207, 
  
  
 Pages: 207–16,</ref>

CIA is induced in mice by injecting them with an emulsion of complete Freund's adjuvant and type II collagen.<ref name=Brand2007>,

 Collagen-induced arthritis, 
 Nat Protoc, 
 2007,
 Vol. 2(Issue: 5),
 pp. 1269–75,
 DOI: 10.1038/nprot.2007.173,
 PMID: 17546023,</ref>

In rats, only one injection is needed, but mice are normally injected twice.<ref name=kato1996>Arthritis in mice induced by a single immunisation with collagen </ref>

References

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