Delafloxacin: Difference between revisions
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{{Short description|An | {{Short description|An antibiotic used to treat bacterial infections}} | ||
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'''Delafloxacin''' is a [[fluoroquinolone]] [[antibiotic]] used in the treatment of | [[File:Delafloxacin.svg|thumb|right|Chemical structure of Delafloxacin]] | ||
'''Delafloxacin''' is a [[fluoroquinolone]] [[antibiotic]] used in the treatment of various bacterial infections. It is particularly effective against [[Gram-positive bacteria]], including [[methicillin-resistant Staphylococcus aureus]] (MRSA), and some [[Gram-negative bacteria]]. Delafloxacin is marketed under the brand name '''Baxdela'''. | |||
==Mechanism of Action== | ==Mechanism of Action== | ||
Delafloxacin works by inhibiting bacterial [[DNA gyrase]] and [[topoisomerase IV]], enzymes critical for [[DNA replication]] and [[transcription]]. | Delafloxacin works by inhibiting bacterial [[DNA gyrase]] and [[topoisomerase IV]], enzymes critical for [[DNA replication]] and [[transcription]]. By interfering with these enzymes, delafloxacin prevents the bacteria from reproducing and repairing their DNA, leading to bacterial cell death. | ||
==Pharmacokinetics== | ==Pharmacokinetics== | ||
Delafloxacin is available in both oral and intravenous formulations. It is well absorbed when taken orally, with a bioavailability of approximately 60%. The drug is widely distributed throughout the body and is primarily excreted via the | Delafloxacin is available in both oral and intravenous formulations, allowing for flexible administration depending on the clinical scenario. It is well absorbed when taken orally, with a bioavailability of approximately 60%. The drug is widely distributed throughout the body and is primarily excreted via the kidneys. | ||
==Clinical Uses== | ==Clinical Uses== | ||
Delafloxacin is approved for the treatment of [[acute bacterial skin and skin structure infections]] (ABSSSI) and [[community-acquired bacterial pneumonia]] (CABP). Its broad | Delafloxacin is approved for the treatment of [[acute bacterial skin and skin structure infections]] (ABSSSI) and [[community-acquired bacterial pneumonia]] (CABP). Its broad spectrum of activity makes it a valuable option in treating infections caused by resistant bacteria. | ||
==Side Effects== | ==Side Effects== | ||
Common side effects of delafloxacin include [[nausea]], [[diarrhea]], and [[headache]]. Like other fluoroquinolones, it carries a risk of [[ | Common side effects of delafloxacin include [[nausea]], [[diarrhea]], and [[headache]]. Like other fluoroquinolones, it carries a risk of more serious side effects such as [[tendonitis]] and [[tendon rupture]], [[peripheral neuropathy]], and [[central nervous system]] effects. Patients are advised to report any unusual symptoms to their healthcare provider. | ||
== | ==Contraindications== | ||
Delafloxacin should not be used in patients with a known hypersensitivity to fluoroquinolones. Caution is advised in patients with a history of [[seizures]] or other central nervous system disorders. | |||
==Related | ==Related Pages== | ||
* [[Fluoroquinolone]] | * [[Fluoroquinolone]] | ||
* [[Antibiotic | * [[Antibiotic]] | ||
* [[Methicillin-resistant Staphylococcus aureus]] | * [[Methicillin-resistant Staphylococcus aureus]] | ||
* [[Bacterial infection]] | |||
[[Category:Antibiotics]] | [[Category:Antibiotics]] | ||
[[Category:Fluoroquinolones]] | [[Category:Fluoroquinolones]] | ||
Latest revision as of 11:40, 23 March 2025
An antibiotic used to treat bacterial infections
Delafloxacin is a fluoroquinolone antibiotic used in the treatment of various bacterial infections. It is particularly effective against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), and some Gram-negative bacteria. Delafloxacin is marketed under the brand name Baxdela.
Mechanism of Action[edit]
Delafloxacin works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes critical for DNA replication and transcription. By interfering with these enzymes, delafloxacin prevents the bacteria from reproducing and repairing their DNA, leading to bacterial cell death.
Pharmacokinetics[edit]
Delafloxacin is available in both oral and intravenous formulations, allowing for flexible administration depending on the clinical scenario. It is well absorbed when taken orally, with a bioavailability of approximately 60%. The drug is widely distributed throughout the body and is primarily excreted via the kidneys.
Clinical Uses[edit]
Delafloxacin is approved for the treatment of acute bacterial skin and skin structure infections (ABSSSI) and community-acquired bacterial pneumonia (CABP). Its broad spectrum of activity makes it a valuable option in treating infections caused by resistant bacteria.
Side Effects[edit]
Common side effects of delafloxacin include nausea, diarrhea, and headache. Like other fluoroquinolones, it carries a risk of more serious side effects such as tendonitis and tendon rupture, peripheral neuropathy, and central nervous system effects. Patients are advised to report any unusual symptoms to their healthcare provider.
Contraindications[edit]
Delafloxacin should not be used in patients with a known hypersensitivity to fluoroquinolones. Caution is advised in patients with a history of seizures or other central nervous system disorders.
