Wobble

Wobble is a phenomenon in molecular biology that refers to the flexibility in the pairing of base pairs at the third codon position in the genetic code. This concept was first proposed by Francis Crick in 1966.

Overview

The wobble hypothesis suggests that the initial two base pairs in an RNA codon bind normally to the corresponding base pairs in a tRNA anticodon, while the third base pair is less constrained and can thus "wobble". This allows for a smaller number of tRNAs to translate the entire genetic code, as a single tRNA molecule can pair with more than one codon.

Implications

The wobble hypothesis has significant implications for protein synthesis and genetic evolution. It allows for a certain degree of mutation without affecting the protein that is produced, contributing to genetic diversity and evolution. It also has implications for the efficiency of protein synthesis, as fewer tRNA molecules are needed to translate the genetic code.

See also

• Genetic code
• Codon
• Anticodon
• tRNA
• Francis Crick

References

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