Keratin 10

Keratin 10 (also known as KRT10) is a type of keratin protein that is primarily found in the upper layer of the epidermis. It is encoded by the KRT10 gene in humans.

Structure

Keratin 10 is a type I cytokeratin, one of the two types of keratin proteins. It is a fibrous protein that forms the intermediate filaments in epithelial cells. The structure of keratin 10 is characterized by a central alpha-helical rod domain that is flanked by non-helical head (N-terminal) and tail (C-terminal) domains.

Function

Keratin 10 plays a crucial role in maintaining the structural integrity of the epidermis. It contributes to the formation of the cornified envelope, a layer of dead skin cells that serves as a barrier to protect the body from environmental damage and water loss.

Clinical significance

Mutations in the KRT10 gene can lead to various skin disorders. For instance, Epidermolytic hyperkeratosis, a rare skin disorder characterized by blistering and thickening of the skin, is often caused by mutations in the KRT10 gene.

See also

• Keratin
• Epidermolytic hyperkeratosis
• Cytokeratin

References

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