UGT1A5

UGT1A5 is an enzyme that is encoded by the UGT1A5 gene in humans. It is part of the UDP-glucuronosyltransferase (UGT) family, which plays a crucial role in the metabolism of endogenous and exogenous compounds.

Function

The UGT1A5 enzyme is involved in the process of glucuronidation, a major pathway for the elimination of potentially toxic xenobiotics and endogenous compounds. This process involves the transfer of glucuronic acid from UDP-glucuronic acid to a substrate molecule, thereby increasing its solubility and facilitating its excretion from the body.

Clinical Significance

Alterations in the UGT1A5 gene can lead to changes in the function of the UGT1A5 enzyme, which can have significant clinical implications. For example, mutations in this gene have been associated with Gilbert's syndrome, a benign condition characterized by intermittent mild jaundice due to the reduced ability of the liver to process bilirubin.

Research

Research into the UGT1A5 enzyme and its associated gene is ongoing, with studies investigating its role in drug metabolism and the potential implications for personalized medicine. Understanding the function of this enzyme could lead to the development of new therapeutic strategies for a variety of conditions.

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References

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External links

• GeneCards - UGT1A5
• NCBI - UGT1A5

See also

• UDP-glucuronosyltransferase
• Glucuronidation
• Gilbert's syndrome

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