Estromustine

Estromustine is a type of chemotherapy drug used in the treatment of prostate cancer. It is a combination of two drugs, estrogen and alkylating agent, which work together to slow or stop the growth of cancer cells.

Mechanism of Action

Estromustine works by disrupting the function of cancer cells. The estrogen component of the drug binds to estrogen receptors on the cancer cells, inhibiting their growth and division. The alkylating agent component of the drug damages the DNA of the cancer cells, preventing them from dividing and growing.

Side Effects

Like all chemotherapy drugs, estromustine can cause side effects. These may include:

• Nausea and vomiting
• Diarrhea
• Fatigue
• Hot flashes
• Breast enlargement in men
• Blood clots

Patients should discuss these potential side effects with their healthcare provider before starting treatment with estromustine.

Drug Interactions

Estromustine can interact with other medications, which can affect how it works or increase the risk of side effects. These include:

• Blood thinners
• Diabetes medications
• Antibiotics
• Antifungal medications
• HIV/AIDS medications

Patients should inform their healthcare provider of all medications they are currently taking before starting treatment with estromustine.

Precautions

Before starting treatment with estromustine, patients should discuss their medical history with their healthcare provider. This includes any history of heart disease, liver disease, kidney disease, or blood clotting disorders.

See Also

• Chemotherapy
• Prostate cancer
• Estrogen
• Alkylating agent

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