Gamithromycin: Difference between revisions

Latest revision as of 11:01, 15 February 2025

Gamithromycin[edit]

Gamithromycin is a macrolide antibiotic used primarily in veterinary medicine. It is a member of the azalide subclass of macrolides, which are characterized by a 15-membered lactone ring. Gamithromycin is specifically used to treat bovine respiratory disease (BRD) in cattle.

Mechanism of Action[edit]

Gamithromycin works by inhibiting bacterial protein synthesis. It binds to the 50S subunit of the bacterial ribosome, thereby preventing the translocation of peptides. This action is bacteriostatic, meaning it inhibits the growth and reproduction of bacteria rather than killing them directly.

Pharmacokinetics[edit]

After administration, gamithromycin is rapidly absorbed and distributed throughout the body. It has a long half-life, which allows for sustained therapeutic concentrations in the tissues. This property makes it particularly effective for treating respiratory infections in cattle, as it maintains effective drug levels in the lungs.

Clinical Use[edit]

Gamithromycin is indicated for the treatment of bovine respiratory disease (BRD) associated with Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni. It is administered as a single subcutaneous injection, which is convenient for use in cattle.

Safety and Side Effects[edit]

Gamithromycin is generally well-tolerated in cattle. However, as with all antibiotics, there is a risk of developing antibiotic resistance. It is important to use gamithromycin judiciously and according to veterinary guidelines to minimize this risk.

Related Pages[edit]

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-{{Infobox drug
+== Gamithromycin ==
-| Watchedfields = changed
-| verifiedrevid = 470604356
-| IUPAC_name = (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one
-| image =
-| tradename =
-| Drugs.com =
-| pregnancy_AU =
-| pregnancy_US =
-| legal_AU =
-| legal_CA =
-| legal_UK =
-| legal_US =
-| legal_status =
-| routes_of_administration =
-| bioavailability =
-| protein_bound =
-| metabolism =
-| elimination_half-life =
-| excretion =
-}}
-'''Gamithromycin''' is a [[macrolide]] [[antibiotic]] used primarily in [[veterinary medicine]] to treat bacterial infections in animals. It is particularly effective against certain types of bacteria that affect respiratory systems in cattle, such as ''Mycoplasma bovis'', which causes bovine respiratory disease (BRD).
+[[File:Gamithromycin.svg|thumb|right|Chemical structure of Gamithromycin]]
-==Chemistry==
+'''Gamithromycin''' is a [[macrolide antibiotic]] used primarily in veterinary medicine. It is a member of the [[azalide]] subclass of macrolides, which are characterized by a 15-membered lactone ring. Gamithromycin is specifically used to treat [[bovine respiratory disease]] (BRD) in cattle.
-Gamithromycin is a semi-synthetic macrolide antibiotic derived from [[erythromycin]]. Its chemical structure is characterized by a large macrocyclic lactone ring, and it is known for its effectiveness against gram-positive bacteria and certain gram-negative bacteria. The drug operates by inhibiting protein synthesis in bacteria, thereby stopping bacterial growth.
-==Pharmacology==
+== Mechanism of Action ==
-###Mechanism of Action
-Gamithromycin works by binding to the 50S ribosomal subunit of susceptible bacteria, inhibiting RNA-dependent protein synthesis. This action prevents the replication of bacteria and effectively controls the spread of infection.
-###Pharmacokinetics
+Gamithromycin works by inhibiting bacterial [[protein synthesis]]. It binds to the 50S subunit of the bacterial [[ribosome]], thereby preventing the translocation of peptides. This action is bacteriostatic, meaning it inhibits the growth and reproduction of bacteria rather than killing them directly.
-The pharmacokinetic properties of gamithromycin include good absorption and distribution in animal tissues, particularly lung tissue, which is crucial for its effectiveness in treating respiratory infections. It is administered via subcutaneous injection, ensuring rapid and targeted delivery to infected areas.
-==Usage==
+== Pharmacokinetics ==
-###Veterinary Applications
-Gamithromycin is primarily used in the treatment of bovine respiratory disease (BRD), also known as shipping fever. It is also used to treat other bacterial infections in animals, including swine and poultry. The drug is appreciated for its long action, which often requires only a single dose to achieve its therapeutic effect.
-==Side Effects and Safety==
+After administration, gamithromycin is rapidly absorbed and distributed throughout the body. It has a long half-life, which allows for sustained therapeutic concentrations in the tissues. This property makes it particularly effective for treating respiratory infections in cattle, as it maintains effective drug levels in the lungs.
-While generally safe and effective when used as directed, gamithromycin can cause some side effects in animals, including injection site reactions and gastrointestinal disturbances. As with all antibiotics, there is a concern about the development of antibiotic resistance, which can occur when the drug is used excessively or improperly.
-==Regulatory Status==
+== Clinical Use ==
-Gamithromycin is approved for use in various countries, subject to veterinary prescription and regulation. Its use is monitored to ensure it is applied responsibly to minimize the risk of antibiotic resistance development.
+Gamithromycin is indicated for the treatment of [[bovine respiratory disease]] (BRD) associated with [[Mannheimia haemolytica]], [[Pasteurella multocida]], and [[Histophilus somni]]. It is administered as a single subcutaneous injection, which is convenient for use in cattle.
+== Safety and Side Effects ==
+Gamithromycin is generally well-tolerated in cattle. However, as with all antibiotics, there is a risk of developing [[antibiotic resistance]]. It is important to use gamithromycin judiciously and according to veterinary guidelines to minimize this risk.
+== Related Pages ==
+* [[Macrolide antibiotics]]
+* [[Bovine respiratory disease]]
+* [[Antibiotic resistance]]
+[[Category:Macrolide antibiotics]]
 [[Category:Veterinary drugs]]
-[[Category:Macrolide antibiotics]]
-{{medicine-stub}}