Sucrose intolerance: Difference between revisions
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{{Short description|Overview of sucrose intolerance}} | |||
{{Medical resources}} | |||
== Overview == | |||
[[File:Sucrose-inkscape.svg|thumb|right|Chemical structure of sucrose]] | |||
'''Sucrose intolerance''', also known as '''congenital sucrase-isomaltase deficiency''' (CSID), is a condition where an individual lacks the enzyme needed to digest [[sucrose]], a common sugar found in many foods. This enzyme deficiency leads to gastrointestinal symptoms when sucrose is consumed. | |||
== | == Pathophysiology == | ||
Sucrose intolerance is caused by a deficiency in the enzyme [[sucrase-isomaltase]], which is responsible for breaking down sucrose into [[glucose]] and [[fructose]]. This enzyme is located on the brush border of the [[small intestine]]. When sucrase-isomaltase is deficient or absent, sucrose cannot be properly digested, leading to symptoms such as [[diarrhea]], [[abdominal pain]], and [[bloating]]. | |||
Sucrose intolerance is caused by | |||
== Symptoms == | == Symptoms == | ||
The symptoms of sucrose intolerance can vary in severity and may include: | |||
* Chronic diarrhea | |||
* Abdominal pain and cramping | |||
* Bloating and gas | |||
* Nausea | |||
* Vomiting | |||
These symptoms typically occur after the ingestion of foods containing sucrose. | |||
== Diagnosis == | == Diagnosis == | ||
Diagnosis of sucrose intolerance can be challenging and often involves a combination of dietary history, symptom assessment, and diagnostic tests. Common diagnostic methods include: | |||
* '''Breath hydrogen test''': Measures hydrogen in the breath after ingestion of sucrose. | |||
* '''Sucrose tolerance test''': Monitors blood glucose levels after sucrose ingestion. | |||
* '''Genetic testing''': Identifies mutations in the sucrase-isomaltase gene. | |||
== Management == | |||
Management of sucrose intolerance primarily involves dietary modification to limit or avoid sucrose intake. Patients may benefit from: | |||
== | * '''Sucrose-free diet''': Avoiding foods high in sucrose such as sweets, certain fruits, and processed foods. | ||
* '''Enzyme replacement therapy''': Use of enzyme supplements to aid in the digestion of sucrose. | |||
== | == Prognosis == | ||
With appropriate dietary management and enzyme supplementation, individuals with sucrose intolerance can lead normal, healthy lives. Early diagnosis and intervention are crucial to prevent complications and improve quality of life. | |||
== Related pages == | |||
* [[Lactose intolerance]] | * [[Lactose intolerance]] | ||
* [[Fructose malabsorption]] | * [[Fructose malabsorption]] | ||
* [[ | * [[Carbohydrate metabolism]] | ||
[[Category:Digestive diseases]] | |||
[[Category:Genetic disorders]] | [[Category:Genetic disorders]] | ||
Revision as of 12:01, 15 February 2025
Overview of sucrose intolerance
Overview
Sucrose intolerance, also known as congenital sucrase-isomaltase deficiency (CSID), is a condition where an individual lacks the enzyme needed to digest sucrose, a common sugar found in many foods. This enzyme deficiency leads to gastrointestinal symptoms when sucrose is consumed.
Pathophysiology
Sucrose intolerance is caused by a deficiency in the enzyme sucrase-isomaltase, which is responsible for breaking down sucrose into glucose and fructose. This enzyme is located on the brush border of the small intestine. When sucrase-isomaltase is deficient or absent, sucrose cannot be properly digested, leading to symptoms such as diarrhea, abdominal pain, and bloating.
Symptoms
The symptoms of sucrose intolerance can vary in severity and may include:
- Chronic diarrhea
- Abdominal pain and cramping
- Bloating and gas
- Nausea
- Vomiting
These symptoms typically occur after the ingestion of foods containing sucrose.
Diagnosis
Diagnosis of sucrose intolerance can be challenging and often involves a combination of dietary history, symptom assessment, and diagnostic tests. Common diagnostic methods include:
- Breath hydrogen test: Measures hydrogen in the breath after ingestion of sucrose.
- Sucrose tolerance test: Monitors blood glucose levels after sucrose ingestion.
- Genetic testing: Identifies mutations in the sucrase-isomaltase gene.
Management
Management of sucrose intolerance primarily involves dietary modification to limit or avoid sucrose intake. Patients may benefit from:
- Sucrose-free diet: Avoiding foods high in sucrose such as sweets, certain fruits, and processed foods.
- Enzyme replacement therapy: Use of enzyme supplements to aid in the digestion of sucrose.
Prognosis
With appropriate dietary management and enzyme supplementation, individuals with sucrose intolerance can lead normal, healthy lives. Early diagnosis and intervention are crucial to prevent complications and improve quality of life.
