Persomics: Difference between revisions

Latest revision as of 04:06, 13 February 2025

Persomics[edit]

The logo of Persomics

Persomics is a biotechnology company that specializes in the development of innovative tools for high-throughput genomics and phenotypic screening. The company is known for its unique approach to genome editing and functional genomics, enabling researchers to conduct large-scale experiments with ease and efficiency.

Overview[edit]

Persomics was founded with the goal of simplifying the process of genetic screening by miniaturizing and automating the experimental workflow. The company's technology allows for the simultaneous testing of thousands of genetic perturbations in a single experiment, significantly reducing the time and cost associated with traditional methods.

Technology[edit]

The core technology of Persomics involves the use of microarray plates that contain thousands of different siRNA or CRISPR constructs. These plates are used to transfect cells in a high-throughput manner, allowing researchers to observe the effects of gene knockdown or knockout across a wide array of conditions.

Microarray Plates[edit]

File:Persomics logo.svg

Persomics microarray plates enable high-throughput screening.

The microarray plates developed by Persomics are designed to be compatible with standard laboratory equipment, making them accessible to a wide range of researchers. Each well of the plate contains a unique genetic construct, allowing for the parallel analysis of multiple genes.

Applications[edit]

Persomics' technology is used in various fields of biomedical research, including cancer research, drug discovery, and genetic disease studies. By enabling high-throughput screening, researchers can quickly identify potential targets for therapeutic intervention and gain insights into complex biological processes.

Advantages[edit]

The main advantages of Persomics' approach include:

Scalability: The ability to test thousands of genetic perturbations simultaneously.
Cost-effectiveness: Reduced costs compared to traditional screening methods.
Speed: Faster experimental turnaround times.
Flexibility: Compatible with a wide range of cell types and experimental conditions.

Related pages[edit]

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-'''Persomics''' is a technology-driven approach that aims to revolutionize the field of [[genomics]] by enabling high-throughput functional genomics studies. This innovative method leverages the power of miniaturized and parallel assays to study the effects of gene perturbations on a large scale. Persomics technology integrates advancements in [[microarray]] technology, [[genetic screening]], and [[image analysis]] to facilitate rapid and cost-effective functional analysis of genes in a variety of biological contexts.
+== Persomics ==
-==Overview==
+[[File:Persomics_logo.svg|thumb|right|The logo of Persomics]]
-Persomics technology is built upon the concept of using miniaturized assays to perform thousands of parallel experiments on a single [[cell culture]] or [[microarray]] slide. This approach allows for the systematic perturbation of genes using techniques such as RNA interference (RNAi) or CRISPR-Cas9 mediated gene editing. Each spot on a Persomics array can represent a different gene target, enabling the simultaneous investigation of multiple gene functions within a single experiment.
-==Applications==
+'''Persomics''' is a biotechnology company that specializes in the development of innovative tools for high-throughput [[genomics]] and [[phenotypic screening]]. The company is known for its unique approach to [[genome editing]] and [[functional genomics]], enabling researchers to conduct large-scale experiments with ease and efficiency.
-The applications of Persomics technology are vast and span across various fields of biological research and drug discovery. Key applications include:
-* '''Functional Genomics:''' Understanding the role of genes in biological processes and diseases by observing the phenotypic outcomes of gene perturbations.
+== Overview ==
-* '''Drug Discovery:''' Identifying potential drug targets by screening for genes that, when inhibited or activated, affect disease-related phenotypes.
-* '''Genetic Screening:''' High-throughput screening of genetic mutations and their effects on cell behavior, useful in both research and clinical diagnostics.
-* '''Pathway Analysis:''' Elucidating the molecular pathways that underlie biological processes and disease mechanisms by analyzing the effects of gene perturbations on these pathways.
-==Technology==
+Persomics was founded with the goal of simplifying the process of [[genetic screening]] by miniaturizing and automating the experimental workflow. The company's technology allows for the simultaneous testing of thousands of genetic perturbations in a single experiment, significantly reducing the time and cost associated with traditional methods.
-The core of Persomics technology involves the use of high-density, miniaturized arrays that can contain thousands of spots, each spot being a site for gene perturbation. These arrays are typically applied to cell cultures, where each spot delivers a specific gene-silencing agent (such as a small interfering RNA, siRNA) or a gene-editing component (such as a CRISPR-Cas9 guide RNA). Following the application of these arrays and the incubation of the cell cultures, high-resolution imaging and automated image analysis are used to assess the phenotypic outcomes of the gene perturbations.
-==Advantages==
+== Technology ==
-Persomics technology offers several advantages over traditional methods of functional genomics and genetic screening, including:
-* '''High Throughput:''' The ability to perform thousands of experiments in parallel significantly reduces the time and cost associated with functional genomics studies.
+The core technology of Persomics involves the use of microarray plates that contain thousands of different [[siRNA]] or [[CRISPR]] constructs. These plates are used to transfect cells in a high-throughput manner, allowing researchers to observe the effects of gene knockdown or knockout across a wide array of conditions.
-* '''Scalability:''' The miniaturized nature of the assays allows for scalability, from small-scale targeted studies to large-scale screens.
-* '''Versatility:''' Compatible with various cell types and perturbation methods, making it applicable to a wide range of biological questions and experimental setups.
-* '''Reduced Material Use:''' The miniaturized assays require less biological and chemical material, reducing the overall cost and environmental impact of research.
-==Challenges==
+=== Microarray Plates ===
-Despite its advantages, the implementation of Persomics technology faces several challenges, including the need for specialized equipment for array fabrication and analysis, the requirement for high-quality and specific reagents for gene perturbation, and the complexity of data analysis and interpretation.
-==Future Directions==
+[[File:Persomics_logo.svg|thumb|left|Persomics microarray plates enable high-throughput screening.]]
-The future of Persomics technology lies in its potential to further democratize functional genomics research by making high-throughput genetic screening more accessible and cost-effective. Ongoing advancements in microarray technology, gene editing tools, and computational methods for data analysis are expected to enhance the capabilities and applications of Persomics technology.
-[[Category:Genomics]]
+The microarray plates developed by Persomics are designed to be compatible with standard laboratory equipment, making them accessible to a wide range of researchers. Each well of the plate contains a unique genetic construct, allowing for the parallel analysis of multiple genes.
-[[Category:Biotechnology]]
-[[Category:Genetic engineering]]
-{{stub}}
+=== Applications ===
+Persomics' technology is used in various fields of [[biomedical research]], including [[cancer research]], [[drug discovery]], and [[genetic disease]] studies. By enabling high-throughput screening, researchers can quickly identify potential targets for therapeutic intervention and gain insights into complex biological processes.
+== Advantages ==
+The main advantages of Persomics' approach include:
+* '''Scalability''': The ability to test thousands of genetic perturbations simultaneously.
+* '''Cost-effectiveness''': Reduced costs compared to traditional screening methods.
+* '''Speed''': Faster experimental turnaround times.
+* '''Flexibility''': Compatible with a wide range of cell types and experimental conditions.
+== Related pages ==
+* [[Genomics]]
+* [[CRISPR]]
+* [[siRNA]]
+* [[Phenotypic screening]]
+* [[Biotechnology]]
+[[Category:Biotechnology companies]]