KLF2: Difference between revisions

KLF2
Symbol	KLF2
HGNC ID	6347
Alternative symbols	–
Entrez Gene	10365
OMIM	602016
RefSeq	NM_016270
UniProt	Q9Y5W3
Chromosome	19p13.11
Locus supplementary data	–

Latest revision as of 20:43, 30 December 2024

KLF2 (Kruppel-like factor 2) is a transcription factor that plays a crucial role in the regulation of gene expression in endothelial cells. It is part of the Kruppel-like factor family, which is involved in various cellular processes including cell proliferation, differentiation, and apoptosis.

Function[edit]

KLF2 is primarily expressed in the vascular endothelium and is known to regulate the expression of genes involved in vascular tone, inflammation, and thrombosis. It acts as a key regulator of endothelial homeostasis and is essential for maintaining vascular integrity.

KLF2 modulates the expression of eNOS (endothelial nitric oxide synthase), which is critical for the production of nitric oxide, a molecule that plays a significant role in vasodilation and blood pressure regulation.

Clinical Significance[edit]

Alterations in KLF2 expression have been associated with various cardiovascular diseases, including atherosclerosis, hypertension, and thrombosis. Studies have shown that KLF2 expression is reduced in atherosclerotic lesions, suggesting its protective role against vascular inflammation and plaque formation.

KLF2 is also being studied for its potential role in cancer, as it may influence tumor angiogenesis and metastasis.

Research[edit]

Recent research has focused on the role of KLF2 in immune regulation and its potential as a therapeutic target in autoimmune diseases. KLF2 has been shown to influence the trafficking of lymphocytes and the expression of adhesion molecules, which are critical for immune cell migration.

References[edit]

External Links[edit]

[KLF2 at GeneCards](https://www.genecards.org/cgi-bin/carddisp.pl?gene=KLF2)
[KLF2 at NCBI Gene](https://www.ncbi.nlm.nih.gov/gene/10365)

@@ Line 1: / Line 1: @@
-'''KLF2''' (Kruppel Like Factor 2) is a [[protein]] that in humans is encoded by the '''KLF2''' [[gene]]. It is a member of the [[Kruppel-like factor]] family of [[zinc finger proteins]]. KLF2 plays a crucial role in [[lymphocyte]] trafficking, [[blood vessel]] development, and [[lung]] maturation.
+{{Infobox gene
+| name = KLF2
+| image = <!-- Image of the gene or protein -->
+| caption = <!-- Caption for the image -->
+| HGNCid = 6347
+| symbol = KLF2
+| alt_symbols = LKLF
+| EntrezGene = 10365
+| OMIM = 602016
+| RefSeq = NM_016270
+| UniProt = Q9Y5W3
+| chromosome = 19
+| arm = p
+| band = 13.11
+}}
+'''KLF2''' (Kruppel-like factor 2) is a [[transcription factor]] that plays a crucial role in the regulation of [[gene expression]] in [[endothelial cells]]. It is part of the [[Kruppel-like factor]] family, which is involved in various cellular processes including [[cell proliferation]], [[differentiation]], and [[apoptosis]].
 == Function ==
+KLF2 is primarily expressed in the [[vascular endothelium]] and is known to regulate the expression of genes involved in [[vascular tone]], [[inflammation]], and [[thrombosis]]. It acts as a key regulator of [[endothelial homeostasis]] and is essential for maintaining [[vascular integrity]].
-KLF2 is a [[transcription factor]] that binds to the [[promoter]] regions of its target genes and regulates their expression. It is involved in the regulation of [[T cell]] quiescence and [[endothelial cell]] activation. In [[endothelial cells]], KLF2 regulates the expression of [[thrombomodulin]], a protein that plays a key role in the [[anticoagulant]] pathway.
+KLF2 modulates the expression of [[eNOS]] (endothelial nitric oxide synthase), which is critical for the production of [[nitric oxide]], a molecule that plays a significant role in [[vasodilation]] and [[blood pressure regulation]].
 == Clinical Significance ==
+Alterations in KLF2 expression have been associated with various [[cardiovascular diseases]], including [[atherosclerosis]], [[hypertension]], and [[thrombosis]]. Studies have shown that KLF2 expression is reduced in [[atherosclerotic lesions]], suggesting its protective role against [[vascular inflammation]] and [[plaque formation]].
-Alterations in the expression of KLF2 have been associated with several diseases. For example, reduced expression of KLF2 has been observed in patients with [[atherosclerosis]], and it has been suggested that KLF2 may have a protective role in this disease. In addition, mutations in the KLF2 gene have been identified in patients with [[congenital heart disease]].
+KLF2 is also being studied for its potential role in [[cancer]], as it may influence [[tumor angiogenesis]] and [[metastasis]].
 == Research ==
+Recent research has focused on the role of KLF2 in [[immune regulation]] and its potential as a therapeutic target in [[autoimmune diseases]]. KLF2 has been shown to influence the trafficking of [[lymphocytes]] and the expression of [[adhesion molecules]], which are critical for [[immune cell]] migration.
-Research on KLF2 is ongoing, with studies focusing on its role in [[immune response]], [[cardiovascular disease]], and [[cancer]]. Understanding the function of KLF2 and its role in disease may lead to the development of new therapeutic strategies.
-[[File:KLF2 protein structure.jpg|thumb|right|300px|Structure of the KLF2 protein. Image from Wikimedia Commons.]]
 == See Also ==
-* [[Kruppel-like factors]]
 * [[Transcription factor]]
-* [[Zinc finger protein]]
+* [[Endothelial cell]]
+* [[Vascular biology]]
+* [[Gene expression]]
 == References ==
+<references/>
-<references />
+== External Links ==
+* [KLF2 at GeneCards](https://www.genecards.org/cgi-bin/carddisp.pl?gene=KLF2)
+* [KLF2 at NCBI Gene](https://www.ncbi.nlm.nih.gov/gene/10365)
 [[Category:Transcription factors]]
-[[Category:Human proteins]]
+[[Category:Genes on human chromosome 19]]
-[[Category:Genes]]
+[[Category:Cardiovascular system]]
-[[Category:Medicine]]
+[[Category:Cell biology]]
-{{medicine-stub}}