ZNF19

ZNF19 or Zinc Finger Protein 19 is a protein that in humans is encoded by the ZNF19 gene. The protein encoded by this gene is a member of the krueppel C2H2-type zinc-finger protein family, and it contains one KRAB domain and eighteen C2H2 type zinc fingers.

Function

ZNF19 is a transcription factor that can bind DNA, RNA, and proteins. The protein functions as a regulator of transcription and is involved in cellular processes such as cell differentiation, cell growth, wound healing, and apoptosis.

Structure

The ZNF19 protein is composed of a KRAB domain and eighteen C2H2 type zinc fingers. The KRAB domain is a protein domain found in a subset of zinc finger proteins. It functions as a transcriptional repressor. The C2H2 type zinc fingers are the classical type of zinc finger and are the most common type of zinc finger found in transcription factors.

Clinical Significance

While the exact clinical significance of ZNF19 is not fully understood, it is believed to play a role in various diseases due to its function as a transcription factor. Abnormalities in transcription factors can lead to diseases such as cancer, autoimmune diseases, and developmental disorders.

See Also

• Zinc finger
• Transcription factor
• KRAB domain
• C2H2 type zinc fingers

References

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