TNFRSF12A: Difference between revisions
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'''TNFRSF12A''' | {{DISPLAYTITLE:TNFRSF12A}} | ||
{{Infobox gene | |||
| name = TNFRSF12A | |||
| image = <!-- Image removed --> | |||
| caption = <!-- Caption removed --> | |||
| HGNCid = 11906 | |||
| symbol = TNFRSF12A | |||
| alt_symbols = FN14 | |||
| EntrezGene = 51330 | |||
| OMIM = 604967 | |||
| RefSeq = NM_016639 | |||
| UniProt = Q9NP84 | |||
| chromosome = 16 | |||
| arm = p | |||
| band = 13.3 | |||
}} | |||
'''TNFRSF12A''' (Tumor Necrosis Factor Receptor Superfamily Member 12A) is a [[gene]] that encodes a member of the [[tumor necrosis factor receptor superfamily]]. This receptor is also known as [[FN14]] and is the smallest member of this family. It is involved in various cellular processes, including [[cell proliferation]], [[apoptosis]], and [[inflammation]]. | |||
== Function == | == Function == | ||
TNFRSF12A is a | The TNFRSF12A gene product is a receptor for the [[cytokine]] [[TWEAK]] (TNF-like weak inducer of apoptosis). The interaction between FN14 and TWEAK can activate several signaling pathways, including the [[NF-kB]] pathway, which plays a crucial role in [[immune response]] and [[cell survival]]. | ||
== Clinical Significance == | == Clinical Significance == | ||
Alterations in the expression of TNFRSF12A have been associated with various [[diseases]], including [[cancer]], [[atherosclerosis]], and [[autoimmune disorders]]. Overexpression of FN14 has been observed in several types of [[tumors]], suggesting a role in [[tumor progression]] and [[metastasis]]. | |||
== Research == | == Research == | ||
Research | Research on TNFRSF12A is ongoing to better understand its role in disease and its potential as a [[therapeutic target]]. Studies are exploring the use of FN14 inhibitors in the treatment of [[cancer]] and other diseases characterized by [[chronic inflammation]]. | ||
[[ | |||
== See Also == | == See Also == | ||
* [[Tumor necrosis factor receptor]] | * [[Tumor necrosis factor receptor superfamily]] | ||
* [[ | * [[Cytokine]] | ||
* [[ | * [[Apoptosis]] | ||
* [[NF-kB]] | |||
== References == | == References == | ||
{{Reflist}} | |||
== External Links == | |||
[ | * [https://www.ncbi.nlm.nih.gov/gene/51330 TNFRSF12A Gene - NCBI] | ||
[ | * [https://www.uniprot.org/uniprot/Q9NP84 TNFRSF12A Protein - UniProt] | ||
[[Category:Genes on human chromosome 16]] | |||
[[Category:Tumor necrosis factor receptor superfamily]] | |||
[[Category:Apoptosis]] | |||
[[Category:Immune system]] | |||
Latest revision as of 20:36, 30 December 2024
| Symbol | TNFRSF12A |
|---|---|
| HGNC ID | 11906 |
| Alternative symbols | – |
| Entrez Gene | 51330 |
| OMIM | 604967 |
| RefSeq | NM_016639 |
| UniProt | Q9NP84 |
| Chromosome | 16p13.3 |
| Locus supplementary data | – |
TNFRSF12A (Tumor Necrosis Factor Receptor Superfamily Member 12A) is a gene that encodes a member of the tumor necrosis factor receptor superfamily. This receptor is also known as FN14 and is the smallest member of this family. It is involved in various cellular processes, including cell proliferation, apoptosis, and inflammation.
Function[edit]
The TNFRSF12A gene product is a receptor for the cytokine TWEAK (TNF-like weak inducer of apoptosis). The interaction between FN14 and TWEAK can activate several signaling pathways, including the NF-kB pathway, which plays a crucial role in immune response and cell survival.
Clinical Significance[edit]
Alterations in the expression of TNFRSF12A have been associated with various diseases, including cancer, atherosclerosis, and autoimmune disorders. Overexpression of FN14 has been observed in several types of tumors, suggesting a role in tumor progression and metastasis.
Research[edit]
Research on TNFRSF12A is ongoing to better understand its role in disease and its potential as a therapeutic target. Studies are exploring the use of FN14 inhibitors in the treatment of cancer and other diseases characterized by chronic inflammation.
See Also[edit]
References[edit]
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