ING4: Difference between revisions

ING4
Symbol	ING4
HGNC ID	6071
Alternative symbols	–
Entrez Gene	51147
OMIM	608559
RefSeq	NM_016162
UniProt	Q9UNL4
Chromosome	12p13
Locus supplementary data	–

Latest revision as of 20:47, 30 December 2024

ING4 (Inhibitor of Growth Family Member 4) is a gene that encodes a protein involved in the regulation of cell growth, apoptosis, and tumor suppression. The ING4 protein is part of the inhibitor of growth (ING) family, which plays a crucial role in chromatin remodeling and gene expression regulation.

Function[edit]

The ING4 protein is known to interact with the p53 tumor suppressor protein, enhancing its ability to regulate cell cycle arrest and apoptosis. ING4 is also involved in the NF-kB signaling pathway, where it acts as a negative regulator, thereby inhibiting inflammation and angiogenesis.

Clinical Significance[edit]

Alterations in the ING4 gene have been associated with various types of cancer, including glioblastoma, breast cancer, and lung cancer. Loss of ING4 expression can lead to increased tumor growth and metastasis, highlighting its role as a tumor suppressor.

Interactions[edit]

ING4 has been shown to interact with several proteins, including:

EP300 - a histone acetyltransferase involved in transcriptional activation.
TP53 - a tumor suppressor protein that regulates the cell cycle.
NF-kB - a protein complex that controls transcription of DNA, cytokine production, and cell survival.

Research[edit]

Ongoing research is focused on understanding the precise mechanisms by which ING4 regulates tumor suppression and its potential as a therapeutic target in cancer treatment.

References[edit]

External Links[edit]

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-'''ING4''' or '''Inhibitor of Growth Family Member 4''' is a [[protein]] that in humans is encoded by the ING4 [[gene]]. It is a member of the [[Inhibitor of Growth (ING)]] family, which is a type of [[tumor suppressor]] gene.
+{{Infobox gene
+| name = ING4
+| image = <!-- Image removed -->
+| caption = <!-- Caption removed -->
+| symbol = ING4
+| alt_symbols =
+| EntrezGene = 51147
+| HGNCid = 6071
+| OMIM = 608559
+| RefSeq = NM_016162
+| UniProt = Q9UNL4
+| chromosome = 12
+| arm = p
+| band = 13
+}}
+'''ING4''' (Inhibitor of Growth Family Member 4) is a [[gene]] that encodes a protein involved in the regulation of [[cell growth]], [[apoptosis]], and [[tumor suppression]]. The ING4 protein is part of the inhibitor of growth (ING) family, which plays a crucial role in [[chromatin remodeling]] and [[gene expression]] regulation.
 == Function ==
-The ING4 protein has a [[PHD finger]], which is a common motif in proteins involved in [[chromatin remodeling]]. This protein can bind [[TP53]] and may potentially modulate [[p53]]-dependent [[transcription]] and [[apoptosis]]. ING4 has been shown to suppress cell growth and to be involved in the regulation of [[angiogenesis]].
+The ING4 protein is known to interact with the [[p53]] tumor suppressor protein, enhancing its ability to regulate [[cell cycle arrest]] and [[apoptosis]]. ING4 is also involved in the [[NF-kB]] signaling pathway, where it acts as a negative regulator, thereby inhibiting [[inflammation]] and [[angiogenesis]].
 == Clinical Significance ==
-Alterations in the ING4 gene have been associated with a variety of [[cancer]]s, including [[breast cancer]], [[glioma]], [[head and neck cancer]], and [[hepatocellular carcinoma]]. Studies have suggested that ING4 could serve as a potential [[biomarker]] for these cancers.
+Alterations in the ING4 gene have been associated with various types of [[cancer]], including [[glioblastoma]], [[breast cancer]], and [[lung cancer]]. Loss of ING4 expression can lead to increased tumor growth and metastasis, highlighting its role as a tumor suppressor.
+== Interactions ==
+ING4 has been shown to interact with several proteins, including:
+* [[EP300]] - a histone acetyltransferase involved in transcriptional activation.
+* [[TP53]] - a tumor suppressor protein that regulates the cell cycle.
+* [[NF-kB]] - a protein complex that controls transcription of DNA, cytokine production, and cell survival.
 == Research ==
-Research into the ING4 gene and its associated protein is ongoing, with studies focusing on its role in tumor suppression and potential as a therapeutic target in cancer treatment.
+Ongoing research is focused on understanding the precise mechanisms by which ING4 regulates tumor suppression and its potential as a therapeutic target in cancer treatment.
-[[File:ING4 protein structure.jpg|thumb|right|300px|The structure of the ING4 protein.]]
 == See Also ==
-* [[Inhibitor of Growth (ING)]]
+* [[Inhibitor of Growth Family]]
-* [[Tumor suppressor]]
+* [[Tumor Suppressor Genes]]
-* [[PHD finger]]
+* [[Chromatin Remodeling]]
-* [[TP53]]
-* [[Transcription (genetics)]]
-* [[Apoptosis]]
-* [[Angiogenesis]]
-* [[Cancer]]
-* [[Biomarker]]
 == References ==
-<references />
+<references/>
-[[Category:Genes]]
+== External Links ==
-[[Category:Proteins]]
+* [https://www.ncbi.nlm.nih.gov/gene/51147 ING4 Gene - NCBI]
-[[Category:Tumor suppressors]]
+* [https://www.uniprot.org/uniprot/Q9UNL4 ING4 Protein - UniProt]
-[[Category:Cancer]]
-[[Category:Medical genetics]]
-{{Genes on human chromosome 12}}
+[[Category:Genes on human chromosome 12]]
-{{Tumor suppressor genes}}
+[[Category:Tumor suppressor genes]]
-{{medicine-stub}}
+[[Category:Apoptosis regulators]]