Calsenilin

Calsenilin is a protein that in humans is encoded by the KCNIP3 gene. It is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KChIPs), which belongs to the neuronal calcium sensor family of calcium binding proteins.

Function

Calsenilin is a calcium-binding protein that interacts with the presenilins, which are involved in the release of beta-amyloid peptide during the progression of Alzheimer's disease. It is highly expressed in the brain and is thought to have a role in neuronal function.

Structure

Calsenilin is a small protein of 271 amino acids with a molecular weight of approximately 29 kDa. It contains four EF-hand calcium-binding motifs, which are characteristic of the neuronal calcium sensor family of proteins.

Role in Disease

Calsenilin has been implicated in several neurodegenerative diseases, including Alzheimer's disease and Down syndrome. It is thought to modulate the processing of the amyloid precursor protein (APP), which is involved in the formation of beta-amyloid plaques in the brains of Alzheimer's patients.

Research

Research into the function of calsenilin and its role in disease is ongoing. Current studies are focused on understanding the molecular mechanisms by which calsenilin interacts with other proteins and influences cellular processes.

See Also

• Presenilin
• Alzheimer's disease
• Down syndrome
• Amyloid precursor protein
• Voltage-gated potassium channel

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