Pyoderma gangrenosum: Difference between revisions
mNo edit summary |
CSV import |
||
| Line 1: | Line 1: | ||
{{SI}} | |||
{{Infobox medical condition | |||
[[File: | | name = Pyoderma gangrenosum | ||
| image = [[File:Crohnie_Pyoderma_gangrenosum.jpg|left|thumb|Pyoderma gangrenosum on the leg]] | |||
'''Pyoderma gangrenosum''' is a rare, non-infectious [[skin disease]] that causes large, painful ulcers. It is often associated with systemic diseases such as [[ulcerative colitis]], [[Crohn's disease]], and [[arthritis]]. | | caption = Pyoderma gangrenosum on the leg | ||
| field = [[Dermatology]] | |||
| synonyms = | |||
| symptoms = Painful skin ulcers | |||
| complications = [[Scarring]], [[infection]] | |||
| onset = Any age, commonly 40-60 years | |||
| duration = Chronic | |||
| causes = Unknown, possibly [[immune system]] dysfunction | |||
| risks = [[Inflammatory bowel disease]], [[rheumatoid arthritis]], [[hematological disorders]] | |||
| diagnosis = [[Clinical diagnosis]], [[biopsy]] | |||
| differential = [[Venous ulcer]], [[necrotizing fasciitis]], [[vasculitis]] | |||
| treatment = [[Corticosteroids]], [[immunosuppressive drugs]] | |||
| medication = [[Prednisone]], [[cyclosporine]], [[infliximab]] | |||
| frequency = Rare | |||
| deaths = Rarely fatal | |||
}} | |||
'''Pyoderma gangrenosum''' is a rare, non-infectious [[skin disease]] that causes large, painful ulcers. It is often associated with systemic diseases such as [[ulcerative colitis]], [[Crohn's disease]], and [[arthritis]]. | |||
== Signs and Symptoms == | == Signs and Symptoms == | ||
The initial symptoms of pyoderma gangrenosum often include small, tender bumps or blisters on the skin. These quickly evolve into painful, deep ulcers with a characteristic purplish border. The ulcers can occur anywhere on the body, but are most common on the legs. | The initial symptoms of pyoderma gangrenosum often include small, tender bumps or blisters on the skin. These quickly evolve into painful, deep ulcers with a characteristic purplish border. The ulcers can occur anywhere on the body, but are most common on the legs. | ||
<youtube> | <youtube> | ||
title='''{{PAGENAME}}''' | title='''{{PAGENAME}}''' | ||
movie_url=http://www.youtube.com/v/hfafEHbheWE | movie_url=http://www.youtube.com/v/hfafEHbheWE | ||
&rel=1 | &rel=1 | ||
| Line 18: | Line 32: | ||
height=600 | height=600 | ||
</youtube> | </youtube> | ||
== Causes == | == Causes == | ||
The exact cause of pyoderma gangrenosum is unknown, but it is often associated with systemic diseases such as [[ulcerative colitis]], [[Crohn's disease]], and [[arthritis]]. It is thought to be an [[autoimmune disease]], in which the body's immune system mistakenly attacks its own tissues. | The exact cause of pyoderma gangrenosum is unknown, but it is often associated with systemic diseases such as [[ulcerative colitis]], [[Crohn's disease]], and [[arthritis]]. It is thought to be an [[autoimmune disease]], in which the body's immune system mistakenly attacks its own tissues. | ||
[[File:Pyoderma gangrenosum 01.jpg|left|thumb|500px|Pyoderma gangrenosum ]] | |||
[[File:Pyoderma gangrenosum 01.jpg|thumb|500px|Pyoderma gangrenosum ]] | |||
== Diagnosis == | == Diagnosis == | ||
Diagnosis of pyoderma gangrenosum is primarily based on the appearance of the skin lesions. There is no specific test for the condition, but tests may be done to rule out other conditions that can cause similar skin lesions, such as infection or [[vasculitis]]. | Diagnosis of pyoderma gangrenosum is primarily based on the appearance of the skin lesions. There is no specific test for the condition, but tests may be done to rule out other conditions that can cause similar skin lesions, such as infection or [[vasculitis]]. | ||
== Treatment == | == Treatment == | ||
Treatment of pyoderma gangrenosum typically involves medications to reduce inflammation and suppress the immune system. These may include [[corticosteroids]], [[cyclosporine]], and [[infliximab]]. In severe cases, surgery may be needed to remove dead tissue from the ulcers. | Treatment of pyoderma gangrenosum typically involves medications to reduce inflammation and suppress the immune system. These may include [[corticosteroids]], [[cyclosporine]], and [[infliximab]]. In severe cases, surgery may be needed to remove dead tissue from the ulcers. | ||
== Prognosis == | == Prognosis == | ||
The prognosis for pyoderma gangrenosum varies depending on the severity of the condition and the presence of associated systemic diseases. With treatment, the skin lesions often heal slowly over months to years, but may leave significant scarring. | The prognosis for pyoderma gangrenosum varies depending on the severity of the condition and the presence of associated systemic diseases. With treatment, the skin lesions often heal slowly over months to years, but may leave significant scarring. | ||
== See Also == | == See Also == | ||
* [[Ulcerative colitis]] | * [[Ulcerative colitis]] | ||
| Line 39: | Line 47: | ||
* [[Autoimmune disease]] | * [[Autoimmune disease]] | ||
* [[Vasculitis]] | * [[Vasculitis]] | ||
[[Category:Skin diseases]] | [[Category:Skin diseases]] | ||
[[Category:Autoimmune diseases]] | [[Category:Autoimmune diseases]] | ||
[[Category:Rare diseases]] | [[Category:Rare diseases]] | ||
{{stub}} | {{stub}} | ||
Latest revision as of 20:26, 8 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD's medical weight loss NYC, sleep center NYC
Philadelphia medical weight loss and Philadelphia sleep clinics
| Pyoderma gangrenosum | |
|---|---|
 | |
| Synonyms | |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Painful skin ulcers |
| Complications | Scarring, infection |
| Onset | Any age, commonly 40-60 years |
| Duration | Chronic |
| Types | N/A |
| Causes | Unknown, possibly immune system dysfunction |
| Risks | Inflammatory bowel disease, rheumatoid arthritis, hematological disorders |
| Diagnosis | Clinical diagnosis, biopsy |
| Differential diagnosis | Venous ulcer, necrotizing fasciitis, vasculitis |
| Prevention | N/A |
| Treatment | Corticosteroids, immunosuppressive drugs |
| Medication | Prednisone, cyclosporine, infliximab |
| Prognosis | N/A |
| Frequency | Rare |
| Deaths | Rarely fatal |
Pyoderma gangrenosum is a rare, non-infectious skin disease that causes large, painful ulcers. It is often associated with systemic diseases such as ulcerative colitis, Crohn's disease, and arthritis.
Signs and Symptoms[edit]
The initial symptoms of pyoderma gangrenosum often include small, tender bumps or blisters on the skin. These quickly evolve into painful, deep ulcers with a characteristic purplish border. The ulcers can occur anywhere on the body, but are most common on the legs.
Causes[edit]
The exact cause of pyoderma gangrenosum is unknown, but it is often associated with systemic diseases such as ulcerative colitis, Crohn's disease, and arthritis. It is thought to be an autoimmune disease, in which the body's immune system mistakenly attacks its own tissues.
Diagnosis[edit]
Diagnosis of pyoderma gangrenosum is primarily based on the appearance of the skin lesions. There is no specific test for the condition, but tests may be done to rule out other conditions that can cause similar skin lesions, such as infection or vasculitis.
Treatment[edit]
Treatment of pyoderma gangrenosum typically involves medications to reduce inflammation and suppress the immune system. These may include corticosteroids, cyclosporine, and infliximab. In severe cases, surgery may be needed to remove dead tissue from the ulcers.
Prognosis[edit]
The prognosis for pyoderma gangrenosum varies depending on the severity of the condition and the presence of associated systemic diseases. With treatment, the skin lesions often heal slowly over months to years, but may leave significant scarring.
